Figure 2.
IL-1R signaling plays a crucial role in the clearance of GAS or S. aureus in the blood. (A), Survival of WT and IL-1R-/- mice after an i.v. challenge with 1 × 106 CFU of GAS or 1.5 × 106 CFU of S. aureus. Shown are the cumulative results of two experiments, each conducted with eight animals per group. *, p < 0.05 versus WT mice as determined with a Kaplan–Meier survival plot. Blood colony counts at 24 and 48 h after an i.v. challenge with 1 × 106 CFU of GAS (B,C) or with 1.5 × 106 CFU of S. aureus (D,E). Each determination was conducted with a different animal in the course of one experiment, involving eight animals per group. Horizontal bars indicate mean values. *, p < 0.05 versus WT mice, as determined by one-way analysis of variance and the Student–Keuls–Newman test.