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. 2021 Jan 26;11(2):162. doi: 10.3390/biom11020162

Figure 4.

Figure 4

Effects of rosmarinic acid (RA)-loaded nanovesicles (5, 10 and 20 mg/kg), RA (20 mg/kg) or aminosalicylic acid (5-ASA) (75 mg/kg) on myeloperoxidase activity (a) and tumor necrosis factor alpha levels (b) in DSS-induced colitis in mice. Data are expressed as the mean ± SEM. Mean value was significantly different compared with the sham group (*** p < 0.001; Student t test). Mean value was significantly different compared with DSS group (+ p < 0.05, ++ p < 0.01, +++ p < 0.01; one-way ANOVA followed by Bonferroni’s Multiple Comparison test).