Distances among and within the Saccharomyces species. Distances obtained with standard and genomic Internal Transcribed Spacer (ITS) (expressed as % of substitution in comparison to the type strain) are displayed in panels (a,b), respectively. The standard and genomic distances from Large ribosomal subunit (LSU) markers are reported in panels (c,d), respectively. Each subpanel reports the distances of the strains belonging to the species under study (indicated on the right of the subpanel) with the sequences of the type strains of the three closest species (indicated close to the box). For instance, the topmost subpanel of (a) reports the intra- and interspecific distances of S. bayanus from the sequences of the S. bayanus, S. pastorianus and S. uvarum type strains. The width of each box represents the variability of the distances of the strains of each species from the type strains of the three closest species. The internal variability of each species is indicated by the topmost box of each subpanel. The distances among the means of the species are displayed as the distances between the vertical l, thick segments within the boxes.