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. 2021 Feb 3;10(2):309. doi: 10.3390/cells10020309

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Quantification of CPA3 mRNA expressing mast cell subpopulations within lung anatomical regions. (A–C) Percentage of mRNA-positive MCT and MCTC populations in (A) small airways, (B) pulmonary vessels, and (C) the alveolar parenchyma. (D) Low-magnification spatial distribution maps of CPA3 mRNA expressing MCT and MCTC lung mast cells. For visualization purposes each mast cell has been replaced with enlarged circles that are color coded according to cell mRNA intensity level. (E) Comparisons of mean percentage of MCT and MCTC with very high (mean cell intensity > 1200 a.u.) CPA3 mRNA expression in the alveolar region (Alv), pulmonary vessels (P.V) and small airways (S.A). (F) The quotient of mean subject CPA3 mRNA/CPA3 protein in total distal lung MCT and MCTC populations. Statistics: (A,B,F) The Mann–Whitney test was used to calculate the significance of among mast cell subpopulation in relation to CPA3 protein expression, ns-p > 0.05, *** p ≤ 0.001.