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. 2021 Feb 6;11(8):3813–3829. doi: 10.7150/thno.45690

Figure 5.

Figure 5

The expression of interleukin-6 (IL-6) in blood and brain. The interaction between surgery mice and others was for 1 h and the brain was harvested at various times after the interaction for results presented in panels A to C or at 6 h after the interaction for results presented in panel D. (A) IL-6 expression in the serum. (B) IL-6 expression in the hippocampus. (C) IL-6 expression in the frontal cortex. (D) IL-6 expression in the serum, hippocampus and frontal cortex. Results are mean ± SEM (n = 5 - 6 for panels A to C, 6 - 8 for panel D). * P < 0.05 compared with control. FO: familiar observer; PBS: phosphate buffered saline; SO: separated observer; UO: unfamiliar observer.