The correlations with inflammation and cognitive performances revealed a putative protective role of let-7b-5p in non-progressive phase. (A) Correlation plot between let-7b-5p levels and the count of peripheral T cells of non-PMS (n = 140) at T0. A negative correlation was observed (Spearman’s correlation: rs = −0.216, * p < 0.01). (B,B’) Correlation plot between let-7b-5p levels and Scheme 106. and Phonemic (n = 95) verbal fluency of non-PMS patients at T0. A positive correlation was observed in both executive and categorical memory functions (Spearman’s correlation, B: rs = −0.294, p < 0.01; B’: rs = 0.218, ** p < 0.05).