Table 5.

Summary of ophthalmic clinical observations (anterior and posterior segment). Rabbits received a single sub-Tenon injection of Dx-loaded microspheres in the left eye (LE). The right eye (RE) was used as the control.

Sign	Prescreen		1 day		7 days		14 days		28 days		42 days
	RE	LE	RE	LE	RE	LE	RE	LE	RE	LE	RE	LE
Conjunctival congestion	1/20	2/20	5/20	19/20 *	0/15	7/15 **	0/11	0/11	0/7	0/7	0/6	0/6
Conjunctival discharge	0/20	0/20	0/20	0/20	0/15	0/15	0/11	0/11	0/7	0/7	0/6	0/6
Conjunctival swelling	0/20	0/20	0/20	0/20	0/15	0/15	0/11	0/11	0/7	0/7	0/6	0/6
Aqueous flare	0/20	0/20	0/20	0/20	0/15	0/15	0/11	0/11	0/7	0/7	0/6	0/6
Light reflex	0/20	0/20	0/20	0/20	0/15	0/15	0/11	0/11	0/7	0/7	0/6	0/6
Iris involvement	0/20	0/20	0/20	0/20	0/15	0/15	0/11	0/11	0/7	0/7	0/6	0/6
Surface of cornea cloudiness	0/20	0/20	0/20	0/20	0/15	0/15	0/11	0/11	0/7	0/7	0/6	0/6
Pannus	0/20	0/20	0/20	0/20	0/15	0/15	0/11	0/11	0/7	0/7	0/6	0/6
Fluorescein staining	0/20	0/20	0/20	0/20	0/15	0/15	0/11	0/11	0/7	0/7	0/6	0/6
Lens	0/20	0/20	0/20	0/20	0/15	0/15	0/11	0/11	0/7	0/7	0/6	0/6
Vitreous opacity	0/20	0/20	0/20	0/20	0/15	0/15	0/11	0/11	0/7	0/7	0/6	0/6
Vascular congestion	0/20	0/20	0/20	0/20	0/15	0/15	0/11	0/11	0/7	0/7	0/6	0/6
Vitreous and retinal hemorrhage	0/20	0/20	0/20	0/20	0/15	0/15	0/11	0/11	0/7	0/7	0/6	0/6
Retinal detachment	0/20	0/20	0/20	0/20	0/15	0/15	0/11	0/11	0/7	0/7	0/6	0/6

* Animals showed minimal conjunctival congestion, except two animals that presented mild congestion. ** Animals showed minimal conjunctival congestion, except one animal that presented mild congestion.