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Representative axial T2-weighted images of control BT257 (a) and SF10417 (b) tumor-bearing mice and corresponding in vivo 1H-MRS spectra acquired from 2 × 2 × 2 mm3 voxel marked inside the tumor region in blue (a,b). Quantification of 2-HG, Glu and GLX metabolites in control, AG-881- and BAY-1436032-treated tumors at D7 ± 2 and D15 ± 1 in the BT257 (c), and at D6 ± 2 and D14 ± 2 in the SF10417 models (* p-value < 0.003) (d).
