. 2021 Feb 14;13(2):299. doi: 10.3390/v13020299

Table 3.

Cellular factors and processes important for phenuivirus infectious entry.

Virus	Fusion/Penetration	Cellular Factors in Viral Entry
Virus	Fusion/Penetration	Required	Not Required
DABV	pH~5.6 [64] 60 min (max) [64]	Actin [64], Ca²⁺ channels [65], clathrin [64], dynamin-2 [42,64], glucosylceramide synthase [58], LAMP1 [66], microtubules [64], serine proteases [42], Rab5 [64,66], Rab7 [64,66], SNX11 [66], vATPases [42]	Gangliosides series a and b [58], cathepsin B and L [42], caveolin-1 [64], cholesterol [64], lactosylceramide synthase [58], PAK1 [64], PI3K [42], Rab7 [58], Rac1 [64]
HRTV		Glucosylceramide synthase [58]
RVFV	pH~5.7 [67] 16–24 min (t_1/2) [67]	Actin [68], Ca²⁺ and K⁺ channels [68], caveolin-1 [69], cholesterol [69], clathrin [67], dynamin-2 [67,69], Na⁺/H⁺ exchangers [68], microtubules [68], PI3K [68], PKC [68], PLC [68], PP1/PP2A [69], RNASEK [70], vATPase [67,69]	Actin [67,69], cholesterol [67], clathrin [69], Na⁺/H⁺ exchangers [69], Eps15 [69], PAK1 [69], PI3K [69], Rac1 [69]
UUKV	pH~5.4 [71] 20–30 min (t_1/2) [71]	BMP [72], clathrin [71], HDAC8 [73], LAMP1 [71], microtubules [71], PI3K [71], Rab5 [71], RNASEK [74], temperature [71], VAMP3 [74], vATPase [71]	Rab7 [71]

The cellular factors in blue have been described by independent studies as either required or not required in the cellular entry of the virus. BMP, bis(monoacylglycerol)phosphate; DABV, Dabie virus; HDAC, histone deacetylase 8, LAMP1, lysosome-associated membrane protein 1; PAK1, p21-activated kinase 1; PI3K, phosphoinositide 3-kinase; PLC, phospholipase C; PKC, protein kinase C; PP1/PP2A, protein phosphatase 1/2A; Rab5 and Rab7, Ras-related protein 5 and 7; RVFV, Rift Valley fever virus; RNASEK, ribonuclease K; TOSV, Toscana virus; UUKV, Uukuniemi virus; VAMP3, vesicle-associated membrane protein 3; vATPase, vacuolar-type proton pump ATPase.