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. 2021 Feb 16;10(2):214. doi: 10.3390/pathogens10020214

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Reduction of biofilm metabolic activity of WMR-K at different concentrations on preformed mono and poly-microbial biofilms of K. pneumoniae, C. albicans in 96-well microplate. (n = 3 ± SD). Fresh growth medium containing sub-MIC concentrations of WMR-K (5, 7.5, and 10 μM for K. pneumoniae biofilm; 7.5, 10, 12.5, 25, and 50 μM for C. albicans and for dual-species biofilms) were added in the mature biofilm and incubated for another 24 h. Data with different letters (a–e) are significantly different (two-way ANOVA followed by Tukey’s post hoc test, p < 0.05). Values with dissimilar letters are significantly different from each other (p < 0.05). Values with the same letter are not significantly different (p > 0.05).