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. Author manuscript; available in PMC: 2022 Feb 1.
Published in final edited form as: Microcirculation. 2021 Jan 9;28(2):e12662. doi: 10.1111/micc.12662

Figure 4. Occlusion Index (OI) associates with hydroxyurea (HU) therapy and can be utilized to identify HU non-response in SCD.

Figure 4.

(A) No significant difference was observed in OI when comparing the on-HU subjects (N = 12) to off-HU subjects (N = 6) among the study HbSS population. (B) HU responders (N = 5) had significantly lower OIs compared to HU non-responders (N = 7, P = 0.023, Mann-Whitney). HU responders (N = 5) among the on-HU HbSS subjects had relatively lower OIs compared to off-HU HbSS subjects (N = 6, P = 0.083, Mann-Whitney). No significant difference was observed in the OI between HU non-responders (N = 7) and off-HU HbSS subjects (N = 6). Error bars represent standard deviation (SD). ns, no significance.