Table 2.
Sensitivity analyses of linear MR estimates using data from the primary analytic sample (N= 47,407 from 5 cohorts) or from two-sample estimates from different genome-wide association studies.
| Outcome Tested | Univariable MR of SBP |
Multivariable** MR of SBP (independent of DBP) |
Two-sample$ Multivariable MR of SBP (independent of DBP) |
Two-sample$ Multivariable MR of DBP (independent of SBP) |
||||
|---|---|---|---|---|---|---|---|---|
| HR (95% CI) |
P-value | HR (95% CI) |
P-value | OR (95% CI) |
P-value | OR (95% CI) |
P-value | |
| MI | 1.04 (1.03-1.05) |
<0.0001* | 1.03 (1.02-1.05) |
<0.0001* | 1.03 (1.02-1.04) |
<0.0001* | 1.03 (1.01-1.05) |
0.002 |
| Coronary artery disease | 1.04 (1.02-1.05) |
<0.0001* | 1.04 (1.02-1.05) |
<0.0001* | 1.03 (1.03-1.04) |
<0.0001* | 1.01 (1.00-1.02) |
0.2 |
| Fatal CHD | 1.02 (1.00-1.04) |
0.04 | 1.04 (1.02-1.06) |
<0.0001* | NA | NA | ||
| Heart failure | 1.03 (1.01-1.04) |
<0.0001* | 1.04 (1.03-1.05) |
<0.0001* | 1.02 (1.01-1.02) |
<0.0001* | 1.01 (1.00-1.02) |
0.3 |
| Ischemic stroke | 1.05 (1.03-1.06) |
<0.0001* | 1.03 (1.02-1.05) |
<0.0001* | 1.03 (1.02-1.04) |
<0.0001* | 1.01 (0.99-1.02) |
0.3 |
| Coronary revascularization | 1.04 (1.03-1.05) |
<0.0001* | 1.03 (1.02-1.05) |
<0.0001* | NA | NA | ||
| All-cause mortality | 1.01 (1.00-1.02) |
0.002 | 1.01 (1.01-1.02) |
0.0004* | NA | NA | ||
CHD: Coronary heart disease, CI: Confidence intervals, HR: Hazard ratio, MI: Myocardial infarction, MR: Mendelian randomization, NA: Not applicable, OR: Odds Ratio
*
Significant after Bonferroni adjustment for multiple comparisons
**
Adjusted for age, sex, two genotype principal components, the dummy variable for each substudy, and DBP
†
Adjusted for age, sex, two genotype principal components, the dummy variable for each substudy, and SBP
$
Two-sample multivariable MR analysis based on summary statistics from different GWAS of the exposure and the outcome