Table 1. Results of the test of association between haplotypes of the N-terminal esxH epitope and the geographic region of origin.
| Region 1 | Strains 2 | Association 3 | esxH (A10V) 4 | esxH (A10X) 5 | esxH (N terminus) 6 | |||
|---|---|---|---|---|---|---|---|---|
| Strains | p-value | Strains | p-value | Strains | p-value | |||
| South Asia | 219 | + | 1 | 0.4852 | 6 | 0.385 | 17 | 0.453 |
| Southeast Asia (islands) | 235 | + | 10 | 0.154 | 156 | 0.081 | 171 | 0.174 |
| Southeast Asia (mainland) | 982 | + | 25 | 0.200 | 183 | 0.095 | 210 | 0.196 |
| East Africa | 466 | - | 0 | 0.046 | 1 | 0.034 | 29 | 0.276 |
| East Africa (no Madagascar) | 391 | - | 0 | 0.070 | 0 | 0.018 | 1 | 0.0004 |
| South Africa | 49 | - | 0 | 0.305 | 0 | 0.165 | 0 | 0.013 |
| South America | 77 | - | 0 | 0.496 | 0 | 0.352 | 0 | 0.095 |
1 We included only regions for which the sample size was 25 or more.
2 Total number of L1 strains from each region.
3 All p-values are one-tailed empirical p-values. This column indicates the direction of the association: + we tested for positive association between the derived haplotype(s) and the geographic region; - we tested for negative association between derived haplotype(s) and the geographic region.
4 Number of strains with the derived haplotype caused by the replacement A10V, and results of the test of association.
5 Number of strains with the derived haplotypes caused by any replacement at position 10 (A10X), and results of the test of association.
6 Number of strains with the derived haplotypes caused by any non-synonymous mutations occurred in the first 18 codons of esxH, and results of the test of association.