Figure 2.

Pressures that influence intestinal eosinophil function and phenotype in health and disease. Eosinophil recruitment, accumulation and functional phenotypes in steady state and inflammation are shaped by complex factors, including systemic hormonal and metabolic mediators, the microbiome, the local cytokine milieu, interactions with extracellular matrix components, tissue factors, and epithelial- and immune-cell-derived cytokines. EOS, eosinophil.