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. 2021 Feb 19;13(2):282. doi: 10.3390/pharmaceutics13020282

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Quantification of in vivo fluorescence signal showed prolonged circulation of S100 PEG and fast clearance of other formulations. Signals were evaluated from defined region of interest (ROI) in DiR-loaded liposome-treated female mice (ventral perspective), as assessed by in vivo FI at 0.25, 1, 3, 24 and 48 h post injection. M1 to M6 represent individual mouse values. M1 and M2 were sacrificed at t = 1 h, M3 and M4 at t = 24 h and M5 and M6 at t = 48 h. Presented values are relative to t = 0.25 h.

Quantification of in vivo fluorescence signal showed prolonged circulation of S100 PEG and fast clearance of other formulations. Signals were evaluated from defined region of interest (ROI) in DiR-loaded liposome-treated female mice (ventral perspective), as assessed by in vivo FI at 0.25, 1, 3, 24 and 48 h post injection. M1 to M6 represent individual mouse values. M1 and M2 were sacrificed at t = 1 h, M3 and M4 at t = 24 h and M5 and M6 at t = 48 h. Presented values are relative to t = 0.25 h.