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. 2021 Feb 19;13(2):282. doi: 10.3390/pharmaceutics13020282

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Quantification of ex vivo single organ total radiant efficiencies (TREs) (pre-selected) shows systemic and spatial accumulation of S100 PEG and fast clearance of other formulations via liver and spleen. Signals were evaluated from defined ROI in DiR-loaded liposome-treated excised single organs, as assessed by ex vivo FI. M1 to M6 represent individual female mouse values. M1 and M2 were sacrificed at t = 1 h, M3 and M4 at t = 24 h and M5 and M6 at t = 48 h. Presented values are relative to the TRE of the respective liver.