Abstract
This 1-year follow-up study was conducted on 21 subjects with type 2 diabetes mellitus. We found reduction in glycosylated hemoglobin from 10.5% to 8.1%, and maintenance of BMI z-scores from 3.9 to 3.8. Majority of the patients could be weaned-off from insulin. Heterogeneous presentation, frequent co-morbidities and complications, and familial clustering were observed.
Keywords: Diabetic nephropathy, HbA1C, Outcome
Contributors
The study was conceptualized by HKP, SW and ST; study design was framed by HKP and KN. UG: data collection; HKP, SW, UG: analysis; HKP, KN, SW, ST: clinical management of cases. All authors approve the final manuscript.
Funding
None
Ethics clearance
Mehta Multispeciality Hospitals IEC; No. IRB-MCH/34/2015, dated: July 22, 2015.
Footnotes
Competing interests
None stated.
References
- 1.Bhatia V, Arya V, Dabadghao P, Balasubramanian K, Sharma K. Etiology and outcome of childhood and adolescent diabetes mellitus is North India. J Pediatr Endocrinol Metab. 2004;17:993–9. doi: 10.1515/JPEM.2004.17.7.993. [DOI] [PubMed] [Google Scholar]
- 2.Jevalikar G, Kohli C, Bansal B, et al. Childhood and youth onset diabetes: A single center experience. Indian J Pediatr. 2016;83:792–8. doi: 10.1007/s12098-015-2009-7. [DOI] [PubMed] [Google Scholar]
- 3.Amutha A, Pradeepa R, Chella KS, et al. Lipid profile in childhood-and youth-onset type 2 diabetes and their association with microvascular complications. J Assoc Physicians India. 2017;65:42–47. [PubMed] [Google Scholar]
- 4.Khadilkar V, Yadav S, Agrawal KK, et al. Revised IAP Growth Charts for Height, Weight and Body Mass Index for 5- to 18-Year-Old Indian Children. Indian Pediatr. 2015;52:47–55. doi: 10.1007/s13312-015-0566-5. [DOI] [PubMed] [Google Scholar]
- 5.Singh P, Gandhi S, Malhotra R, Seth A. Impact of using different growth references on interpretation of anthropometric parameters of children aged 8–15 years. Indian Pediatr. 2020;57:124–8. doi: 10.1007/s13312-020-1728-7. [DOI] [PubMed] [Google Scholar]
- 6.Zeitler P, Arslanian S, Fu J, et al. ISPAD Clinical Practice Consensus Guidelines 2018: Type 2 Diabetes Mellitus in Youth. Pediatr Diabetes. 2018;19:28–46. doi: 10.1111/pedi.12719. [DOI] [PubMed] [Google Scholar]
- 7.Hattersley AT, Greeley SAW, Polak M, et al. ISPAD Clinical Practice Consensus Guidelines 2018: The Diagnosis and Management of Monogenic Diabetes in Children and Adolescents. Pediatr Diabetes. 2018;19:47–63. doi: 10.1111/pedi.12772. [DOI] [PubMed] [Google Scholar]
- 8.Wolfsdorf JI, Glaser N, Agus M, et al. ISPAD Clinical Practice Guidelines 2018: Diabetic Ketoacidosis and Hyperglycemic Hyperosmolar State. Pediatr Diabetes. 2018;19:155–77. doi: 10.1111/pedi.12701. [DOI] [PubMed] [Google Scholar]
- 9.Laffel L, Chang N, Grey M, et al. Metformin monotherapy in youth with recent onset type 2 diabetes: Experience from the prerandomization run-in phase of the TODAY study. Pediatr Diabetes. 2012;13:369–75. doi: 10.1111/j.1399-5448.2011.00846.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 10.TODAY Study Group Safety and tolerability of the treatment of youth-onset type 2 diabetes: The TODAY experience. Diabetes Care. 2013;36:1765–71.1. doi: 10.2337/dc12-2390. [DOI] [PMC free article] [PubMed] [Google Scholar]
