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Schematic representation for the synthesis of oxadiazole derivatives (5a–k). Reagents and reaction condition: (i) ClCH2COOC2H5, K2CO3, CH3COCH3, reflux 9h, (ii) NH2NH2.H2O, C2H5OH, reflux 16h, (iii) POCl3, RCOOH (15a–j), C2H5OH, reflux 14 h, (iv) CS2, KOH (15k), reflux 7h, R=C6H5 (15a), 2-NO2C6H4 (15b), 3,5-(NO2)2C6H3 (15c), 2-NH2C6H4 (15d), 4-NH2C6H4 (15e) 2-OHC6H4 (15f), 4-OHC6H4 (15g), 3-C5H4N (15h), H (15i), CH3 (15j), SH (15k).
