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. 2020 Feb 20;106(3):838–846. doi: 10.3324/haematol.2019.236836

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Copyright© 2021 Ferrata Storti Foundation

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Figure 6. — Dickkopf-1 (DKK1)3-76-long peptide (LP) induces DKK1-specific human Tcell responses from myeloma patients. Myeloma patient’s peripheral blood mononuclear cells were stimulated weekly with DKK13-76-LP plus IL-2 and IL-7 in vitro, and the frequency of DKK1-specific CD4+ and CD8+ IFN-g-secreting cells was detected by intracellular staining assay. (A) Representative results of T cells derived from a myeloma patient (MM1; HLA-A0201+ and HLA-DR*4+) and (B) summarized results from all ten myeloma patients at 4 weeks of in vitro stimulation. (C) Cytolytic activity of DKK1-specific T cells derived from MM1 against various target cells including autologous (MM1) or allogeneic (MM2 and MM3) plasma cells, myeloma cell lines, B cells, and K562 cells. MM1 and MM2 are HLA-A0201+; MM3 is HLA-A1+ and A32+; U266 is HLA-A0201+, ARP-1 is HLAA0201^-. Representative results from one of three experiments are shown. DC: dendritic cells.