Skip to main content
PLOS One logoLink to PLOS One
. 2021 Mar 4;16(3):e0247812. doi: 10.1371/journal.pone.0247812

Experiences of violence and mental health outcomes among Asian American transgender adults in the United States

Monideepa B Becerra 1,2,*, Erik J Rodriquez 3, Robert M Avina 1,2, Benjamin J Becerra 2,4,*
Editor: Michelle Tye5
PMCID: PMC7932064  PMID: 33662045

Abstract

Purpose

We addressed prevalence and factors associated with mental health outcomes (suicidal behavior and psychological distress) among Asian Americans (AA), who identify as transgender, a key group among sexual and gender minorities that is overlooked and understudied.

Methods

We used data from 2015 United States Transgender Survey during 2019–2020 with our population as census defined AA. Outcomes included suicidal ideation, suicidal thoughts, and serious psychological distress (SPD). Independent variables included any abuse, partner abuse, bathroom-related abuse, and additional covariates. Adjusted odds ratio and 95% confidence interval (aOR; 95% CI) for each outcome are adjusted for age, marital status, citizenship status, education level, employment status, as well as poverty status.

Results

Nearly 67% reported experiencing any abuse, 52% reported abuse from romantic/sexual partner(s), while 29% reported harassment/abuse when trying to use bathrooms. Moreover, 82% reported suicidal thoughts, 40% reported suicidal attempts, and 39% had SPD. Results demonstrated that any abuse/violence had higher odds of suicidal thoughts (adjusted odds ratio [aOR] = 2.67, 95% confidence interval (CI):[1.98–3.58], suicidal attempts (aOR = 2.83, 95% CI:[2.18–3.68]), and SPD (aOR = 1.56, 95% CI:[1.20, 2.04]). Abuse from romantic/sexual partners had higher odds of suicidal thoughts (aOR = 2.47, 95% CI:[1.76–3.47]), suicidal attempts (aOR = 2.17, 95% CI:[1.68–2.80]), and SPD (aOR = 2.72, 95% CI:[2.03–3.63]). Experience of harassment/abuse during bathroom use had increased odds of suicidal attempts (aOR = 1.81, 95% CI:[1.41–2.31]).

Conclusion

Exposure to violence is common among AA transgender individuals and related to negative mental health outcomes. Initiatives to reduce exposure to abuse and providing resources for trauma-informed care are imperative to improve health outcomes.

Introduction

Nearly one in five U.S. adults live with a mental illness, with varying degree of severity, though lowest prevalence has been noted among Asian adults [1]. Despites such data, the literature notes that Asian Americans have low mental health service utilization despite existing need. For example, using the Asian American Quality of Life survey, Jang et al. [2] noted that while 44% of participants had mental distress, only 23% reported any mental health service utilization. Likewise, in summarizing existing literature, Tung [3] noted that only 8.6% of the Asian American population used any mental health related service, as compared to nearly 18% of the general U.S. population. While such literature provide a mix of self-reported and diagnosis results, the overall trends highlight a mental illness burden in the nation. Furthermore, according to recent reports Asian Americans may often view mental illness as signs of “weakness” or disrespect to religious/spiritual beliefs, and discussion of mental illness is often uncommon due to the need to “save face,” thus further stigmatizing mental illness [4,5].

Among the Asian American population, those who identify as a sexual and gender minority (SGM) further share a higher prevalence of mental illness when compared to non-SGM Asian Americans as well as other racial/ethnic SGM populations. For example, according to a recent report, 25% of Asian American SGM adults experienced psychological distress, which was higher than that of any other racial/ethnic SGM group and more than four times higher than Asian Americans who are non-SGM [6]. Further, in a qualitative exploratory study among Filipino SGM population in the U.S., Nadal and Corpus [7] noted that the need to balance multiple identities (cultural and sexual orientation), as well as meeting cultural, religious, and family expectations often cumulatively served as stressors. Such participants also reported experiences of racism from within the SGM population that contributed to such stressors. Likewise, researchers have noted that a cumulative intersection of exogenous and endogenous stressors, such as stigma, culture, internalized stress, as well as poor coping skills and social support, have led to worsening mental and sexual health outcomes of sexual and gender minorities who identify as Asian Americans [8,9]. Additionally, funding analyses have demonstrated that of the more than $100,000 awarded for research on health outcomes for Asian American SGM population, no funding has been allocated for mental health related outcomes for this population, including suicide prevention [6]. Despite such evidence on the higher burden of negative mental health outcomes among Asian American SGM population, little research exists on the factors associated with such outcomes.

An even more vulnerable population among SGM are those who identify as transgender. A major challenge of existing data stems from the aggregation of transgender individuals with that of sexual orientations such as lesbian, gay, and bisexual and referred to as LGBT [10]. This may, in turn, unfairly leave the unique transgender population out of empirical data and/or mask their own set of barriers, regardless of sexual orientation. In fact, population-based surveys among transgender populations remains limited [11,12], with little research on Asian Americans who identify as transgender, though recent reports shed light on such prevalence. For example, results from the National Transgender Discrimination Survey [13] highlighted that transgender respondents who also identified as Asian American, South Asian, Southeast Asian, or Pacific Islander, had higher suicidal attempt (56%), compared to other transgender respondents (41%) and the general U.S. population (4%).

In general, the literature highlights some of the factors that may put SGM at a higher risk of adverse mental health, which include abuse-related factors such as discrimination, harassment, and violence [12], as well as note a higher rate of suicidal behavior among those who identify as transgender, when compared to other sexual minorities [14]. For example, Su et al. noted that the likelihood of depressive symptoms and suicide attempts were significantly higher among transgender youth as compared to those who did not report being transgender [15]. In a study assessing prevalence of health outcomes among transgender and non-transgender patients in a Massachusetts clinic, Reisner et al. found that transgender patients were more likely to report lifetime suicide ideation and suicide attempts as compared to non-transgender patients, as well as a higher rate of social stressors, including abuse [16]. Likewise, a systematic review addressing the barriers to care noted the fear of stigma, stereotyping, lack of competent health professionals, as well as affordability contributed to transgender and gender non-conforming adults from seeking care [17].

Further, in an assessment of experiences of violence and discrimination among the transgender population, Lombardi and colleagues also noted that half of surveyed participants reported an experience of harassment or violence in their lifetime [18]. Using the Nationwide Inpatient Sample, Hanna et al. reported that compared to encounters with cisgender individuals, the odds of mental illness, including anxiety, depression, and psychosis, were all significantly higher among encounters with transgender individuals [19]. The experiences of abuse and how they relate to adverse mental health outcomes with Asian American transgender population, however, remains limited. As such, in this exploratory study, we aimed to address how various experiences of abuse may impact mental health outcomes among Asian American transgender individuals, with a sub-objective of identifying the type of abuse that had the most severe negative role.

Methods

Data source

The 2015 U.S. Transgender Survey (USTS) is a survey conducted by the National Center for Transgender Equality, including a total sample size of 27,715 participants from the United States, DC, and territories. Participants were recruited through purposive and snowball sampling. Survey participants were also informed that “trans” or “transgender” is defined as all trans and non-binary identities for the purposes of the survey and thus was inclusive of identities on the trans spectrum. The survey was also developed with input from experts and advocates. It was administered online to transgender adults in the United States only and was disseminated over a 34-day period through community-based outreach efforts. The survey was made available for web-enabled devices, including, smart phones, tablets, computers, etc. as well as in English and Spanish versions. The survey was made available to all United States’ states and territory, as well as military bases, and to those who were at least 18 years of age during the time of the survey. Respondents included those from all 50 states, DC, as well as military bases overseas and American Samoa, Guam, and Puerto Rico. Additional information regarding the study design are available elsewhere [20]. In this study, all sample sizes are weighted, as provided by USTS.

We focused on the Asian American population who were considered transgender in the context of the aforementioned definition used by USTS. USTS provided a six-category recoded variable for self-reported racial/ethnic group based on the American Community Survey (Alaska Native/American Indian alone, Asian/Native Hawaiian/Pacific Islander, Biracial/Multiracial/Not listed, Black/African American alone, Latino/Latina/Hispanic alone, White/Middle Eastern/North African alone). The Asian American population of this study were defined as those who identified as Asian/Native Hawaiian/Pacific Islander group since only 7.89% were Native Hawaiian/Pacific Islander and thus they were not included in the selection. This study was approved by the Institutional Review Board of California State University, San Bernardino (IRB #IRB-FY2019-192). No competing financial interests exist.

Measures

Outcome variables for this study included USTS-provided dichotomized variables of suicidal thoughts (also referred to as ideation), suicidal attempt, and serious psychological distress. Suicidal thoughts were coded as ever having serious suicidal thoughts, defined by responding yes to either: At any time in the past 12 months did you seriously think about trying to kill yourself? or At any time in your life, have you seriously thought about trying to kill yourself? Suicidal attempt was coded as ever responding yes to: During the past 12 months, did you try to kill yourself? or At any time in your life, did you try to kill yourself? Finally, serious psychological distress was assessed using the Kessler-6 scale and defined as receiving a score of 13 or higher with a Cronbach’s alpha of 0.89 [21].

The independent variables of the study were any abuse/violence, partner abuse/violence, and bathroom use related harassment/abuse. Any abuse/violence was defined as having responded yes to any one of the following questions: In the past year, did anyone verbally harass you for any reason? In the past year, did anyone physically attack you (such as grab you, throw something at you, punch you, use a weapon) for any reason? Have you ever experienced unwanted sexual contact (such as oral, genital, or anal contact or penetration, forced fondling, rape)? OR Now just thinking about the past year, have you experienced unwanted sexual contact (such as oral, genital, or anal contact or penetration, forced fondling, rape)?

Partner abuse/violence was defined as having responded yes to any one of the following questions: Have any of your romantic or sexual partners ever. . .? (a) Tried to keep you from seeing or talking to your family or friends, (b) Kept you from having money for your own use, (c) Kept you from leaving the house when you wanted to go, (d) Hurt someone you love, (e) Threatened to hurt a pet or threatened to take a pet away from you, (f) Wouldn’t let you have your hormones, (g) Wouldn’t let you have other medications, (h) Threatened to call the police on you, (i) Threatened to “out” you, (j) Told you that you weren’t a “real” woman or man, (k) Stalked you, (l) Threatened to use your immigration status against you; OR (m) Have any of your romantic or sexual partners ever. . .? (1) Made threats to physically harm you, (2) Slapped you, (3) Pushed or shoved you, (4) Hit you with a fist or something hard, (5) Kicked you, (6) Hurt you by pulling your hair, (7) Slammed you against something, (8) Forced you to engage in sexual activity, (9) Tried to hurt you by choking or suffocating you, (10) Beaten you, (11) Burned you on purpose, (12) Used a knife or gun on you.

Any harassment/abuse related to bathroom use was coded based on yes responses to any of the following questions: In the past year, did anyone tell or ask you if you were using the wrong bathroom? In the past year, did anyone stop you from entering or deny you access to a bathroom? OR In the past year, were you verbally harassed, physically attacked, or experience unwanted sexual contact when accessing or while using a bathroom?

In addition, the following sociodemographic variables were included in the study as potential covariates: age (18–24 years, 25 to 44 years, 45 years or more), marital status (not currently married, currently married), citizenship status (not a U.S. Citizen, U.S. Citizen), educational attainment (high school or less, some college, associate’s degree, bachelor’s degree, some graduate school or more), employment status (not currently employed, currently employed), and poverty level defined at or near poverty (as provided by USTS).

Data analysis

All descriptive, bivariate, and multivariable analyses utilized survey methods to take into account survey weights and were conducted using SAS v9.4 (SAS Institute, Inc.; Cary, NC). Survey weights were provided to adjust for characteristics of the transgender and U.S. population, including race/ethnicity, age, educational attainment, and income. The survey weights also down-weighted possible respondents who could not be distinguished between 17 and 18 years of age due to their birth year. Descriptive statistics consisted of weighted frequencies (rounded up to nearest whole number, as the weights were provided by USTS as fractions) and percentages. Bivariate survey-weighted chi-square analyses and survey-weighted multivariable logistic regression analyses were used to assess the relationship between abuse, partner abuse, or bathroom problems and outcomes of suicidal ideation, suicidal attempts, and serious psychological distress, with the latter adjusting for the aforementioned demographic variables. Interactions, based on relevant literature, were also assessed between abuse, partner abuse, or bathroom problems with suicidal ideation, suicidal attempts, and serious psychological distress. Sub-analyses were further conducted by specific gender identity and prevalence of abuse types, mental health outcomes, as well as associated regressions. Gender identity provided by USTS included: crossdresser, transgender man, transgender woman, assigned female at birth/gender queer/gender non-binary (AFAB GQ/NB), assigned male at birth/gender queer/gender non-binary (AMAB GQ/NB). Due to low sample size under in some categories, we categorized the gender identity variable as: transgender man, transgender woman, and other. A p-value less than 0.05 determined a statistically significant difference. In addition, p less than .01 and .001 are also provided in tables to demonstrate strength of statistical significance. All were two-tailed analyses. No multicollinearity was present, indicated by a VIF (Variance Inflation Factor) <10.

Results

Table 1 shows the sociodemographic characteristics of the study population (weighted sample = 1,369) in addition to the prevalence of the key variables of this study. All reported percentages have been weighted. A majority of the population (54%) was between 18–24 years old, were not currently married (89.8%), were U.S. citizens (92.5%), had some college, an associate degree, or a bachelor’s degree (77.0%), and were currently employed (66.2%). In addition, 36.9% reported being at or below poverty level.

Table 1. Characteristics of study sample (1,369).

Weighted sample Weighted percent (%)
Demographic Characteristics
Age
    18 to 24 years 739 54.0
    25 to 44 years 535 39.1
    45 years or more 96 7.0
Marital status
    Not currently married 1228 89.8
    Married 140 10.2
Citizenship status
    Not a U.S. Citizen 103 7.5
    U.S. Citizen 1266 92.5
Education level
    High school or less 112 8.1
    Some college, associate, bachelor’s 1054 77.0
    Some graduate or more 204 14.9
Employment status
    Not currently employed 461 33.8
    Currently employed 903 66.2
At or below poverty level 483 36.9
Abuse-related factors
    Any abuse/violence 916 66.9
    Partner abuse/violence 585 52.4
    Harassment/abuse when using bathroom 404 29.5
Mental Health Outcomes
    Suicidal thoughts 1120 81.8
    Suicidal attempt 550 40.3
    Serious psychological distress 528 39.1

With respect to abuse-related factors, a majority of our study population reported experiencing any form of abuse/violence (66.9%) and abuse/violence from romantic/sexual partner (52.4%), while approximately 29.5% reported harassment/abuse when trying to use a bathroom. Among mental health outcomes, suicidal thoughts were highly prevalent (81.8%), 40% reported suicidal attempts, and 39.1% had serious psychological distress.

As noted in Table 2, results of survey weighted bivariate analyses demonstrated that the prevalence of suicidal thoughts (87.3% vs. 70.6%), suicidal attempts (48.6% vs. 23.6%), and serious psychological distress (43.5% vs. 30.4%) were significantly higher among those who were exposed to any abuse/violence. Likewise, suicidal thoughts (88.3% vs. 76.5%), suicidal attempts (53.2% vs. 33.3%), and serious psychological distress (45.3% vs. 25.5%) were also higher among participants who reported romantic/sexual partner abuse/violence. Lastly, suicidal attempts (50.8% vs. 35.8%) were significantly higher among those who experienced harassment/abuse while using the bathroom.

Table 2. Association between sample characteristics and mental health outcomes of suicidal thoughts, suicidal attempts, and serious psychological distress.

Suicidal Thoughts (%) Suicidal Attempt (%) Serious Psychological Distress (%)
Abuse-related Factors
    Any abuse/violence *** *** ***
No 70.6 23.6 30.4
Yes 87.3 48.6 43.5
    Partner abuse/violence *** *** ***
No 76.5 33.3 25.5
Yes 88.3 53.2 45.3
    Harassment/abuse related to bathroom use ***
No 80.6 35.8 38.0
Yes 84.3 50.8 41.8
Demographic Characteristics
    Age *** ***
18 to 24 years 85.32 39.93 51.0
25 to 44 years 79.46 42.57 27.1
45 years or more 67.92 30.77 13.7
    Marital status ** ***
Not currently married 82.81 41.04 41.4
Married 72.87 34.57 17.8
    Citizenship status **
Not a U.S. Citizen 71.43 33.45 30.8
U.S. Citizen 82.66 40.90 39.8
    Education level ** * ***
High school or less 89.86 49.17 50.8
Some college, associate, Bachelor’s 82.42 40.73 42.5
Some graduate or more 74.34 33.63 14.7
    Employment status * ** ***
Not currently employed 84.87 45.58 53.3
Currently employed 80.15 37.52 31.6
    At or below poverty level *** *** ***
No 77.21 37.03 29.4
Yes 89.79 49.00 57.0

Results of survey weighted bivariate analyses (weighted sample = 1,369).

* p < .05.

** p < .01.

*** p < .001.

Table 3 displays the results of survey weighted multivariable logistic regression where the independent factors of any abuse/violence, romantic/sexual partner abuse/violence, and harassment/abuse related to bathroom use were assessed against suicidal thoughts, suicidal attempts, and serious psychological distress in nine distinct models. Presence of any abuse/violence was associated with higher suicidal thoughts (adjusted odds ratio [aOR] = 2.67, 95% confidence interval [CI]: [1.98, 3.58]), suicidal attempts (aOR = 2.83, 95% CI: [2.18, 3.68]), as well as SPD (aOR = 1.56, 95% CI: [1.20, 2.04]). Likewise, partner abuse/violence, was associated with increased suicidal thoughts (aOR = 2.47, 95% CI: [1.76, 3.47]), suicidal attempt (aOR = 2.17, 95% CI: [1.68, 2.80]), and SPD (aOR = 2.72, 95% CI: [2.03, 3.63]). In addition, harassment/abuse related to bathroom use also increased the odds of suicidal attempts (aOR = 181, 95%CI: [1.41, 2.31]). Assessment of interactions did not reveal any significant results.

Table 3. Adjusted odds ratio (OR) and 95% confidence interval (CI) of mental health outcomesa, (weighted sample = 1,369).

Suicidal Thoughts Suicidal Attempt Serious Psychological Distress
Any abuse/violence
    Yes vs. No 2.67 (1.98, 3.58)*** 2.83 (2.18, 3.68)*** 1.56
(1.20, 2.04)***
Partner abuse/violence
    Yes vs. No 2.47 (1.76, 3.47)*** 2.17 (1.68, 2.80)*** 2.72 (2.03, 3.63)***
Harassment/abuse related to bathroom use
    Yes vs. No 1.26 (0.91, 1.74) 1.81 (1.41, 2.31)*** 1.15
(0.89, 1.50)

aModels were adjusted for age, marital status, citizenship status, education level, employment status, and poverty level.

*** p < .001.

Table 4 demonstrates the results of bivariate analyses of prevalence of each type of abuse and each type of mental health outcomes of interest in the study, by that of specific gender identity. The prevalence of any abuse/violence was significantly higher among those who identified as other (gender queer/gender non-binary/crossdresser). On the other hand, trans men had higher prevalence of partner abuse/violence as well as harassment/abuse related to bathroom use. Likewise, suicidal thoughts and attempts were higher among trans men, while prevalence of serious psychological distress was higher among those who identified as other (gender queer/gender non-binary/crossdresser).

Table 4. Bivariate analyses of prevalence (%) of each type of abuse and mental health outcomes, by gender identity (weighted sample = 1,369).

Trans Women Trans Men Other
Any abuse/violence*** 63.1 69.7 76.4
Partner abuse/violence*** 59.0 62.8 57.7
Harassment/abuse related to bathroom use*** 20.8 30.1 27.3
Suicidal Thoughts*** 79.4 84.7 81.4
Suicidal Attempt*** 39.9 44.9 37.2
Serious Psychological Distress*** 34.4 34.8 46.8

*** p < .001.

Table 5 provides the results of regression analysis on the odds of suicidal thoughts, suicidal attempts, and serious psychological distress by presence of each type of mental illness and gender identity. While data on serious psychological distress is limited in its interpretation due to low sample size, the overall trend for suicidal thoughts and attempts are similar for the overall trans population as it was for gender identity-specific sub-analyses. For example, among trans women, men, and those in the other category (non-binary, queer, crossdresser), any abuse/violence experience was significantly associated with suicidal thoughts and attempts. Likewise, a similar significant association was noted between partner abuse and mental health outcomes among each of the gender identity groups.

Table 5. Adjusted odds ratio (OR) and 95% confidence interval (CI) of mental health outcomesa by gender identity group (weighted sample = 1,369).

Suicidal Thoughts Suicidal Attempt Serious Psychological Distress
Any abuse/violence (Yes vs. No)
    Trans Women 2.78 (1.64, 4.70)*** 3.22 (2.01, 5.14)*** 1.03 (0.64, 1.65)
    Trans Men 2.32 (1.20, 4.50)* 2.31 (1.44, 3.69)*** 2.47 (1.40, 4.36)**b
    Other 3.09 (1.96, 4.86)*** 4.55 (2.76, 7.51)*** 1.65 (1.09, 2.49)*
Partner abuse/violence (Yes vs. No)
    Trans Women 3.22 (1.77, 5.85)*** 2.23 (1.37, 3.63)** 1.61 (0.96, 2.72)
    Trans Men 2.98 (1.37, 6.51)** 3.27 (1.99, 5.40)*** 5.10 (2.64, 9.86)***b
    Other 2.13 (1.25, 3.65)** 2.02 (1.35, 3.03)*** 3.09 (1.99, 4.79)***
Harassment/abuse related to bathroom use (Yes vs. No)
    Trans Women 1.25 (0.67, 2.34) 1.80 (1.09, 2.98)* 1.28 (0.75, 2.18)
    Trans Men 0.92 (0.46, 1.82) 1.30 (0.81, 2.10) 1.23 (0.71, 2.12)b
    Other 1.39 (0.86, 2.24) 2.27 (1.57, 3.29)*** 1.13 (0.77, 1.65)

aModels were adjusted for age, marital status, citizenship status, education level, employment status, and poverty level.

bModels did not converge due to quasi-complete separation.

*p<0.05

**p<0.01

*** p < .001.

Discussion

Our study aimed to address a gap in existing research by evaluating the association between exposure to various forms of abuse to that of adverse mental health outcomes, including suicide-related behaviors, among a significantly understudied group: Asian American transgender individuals. The results of our study showed that (a) experiences of abuse, including from a partner, are substantially prevalent among the study participants and (b) these experiences are associated with suicidal thoughts, suicidal attempts, and serious psychological distress.

While literature continues to expand on addressing the prevalence of violence, abuse, and suicidal behaviors among transgender population, there has been little focus on whether abuse-related exposures are related to mental health outcomes, especially among Asian Americans, thus addressing the intersectionality of multiple minority status. In a study based in Northern California among male-to-female transgender women who had a history of sex work, Nemoto et al. reported that more than half of those who were Latina and White reported depression, and factors such as transphobia were significantly related to such an outcome [22]. Likewise, results from the Virginia Transgender Health Initiative Survey from 2005–2006 highlight that suicide attempts were higher among participants who experienced physical and/or sexual violence [23]. Similarly, in a study among transgender population recruited through referral agencies in San Francisco, Clements-Noell et al. noted that among other factors, history of forced sex and gender-based discrimination were independently associated with attempted suicide [24]. Howard et al. [25] further noted in a study in Chicago that among transgender people of color, negative experiences at healthcare settings were driven by discrimination against race/ethnicity and/or gender identity, which further led to participants expecting better treatment if they were cis-gendered or white.

Such observations, coupled with those noted in our study, can inform clinicians and public health practitioners as they design implementation research and plan coordinated care efforts. For example, researchers have called for trauma-informed intersectionality analysis [26] in research among such vulnerable populations. As such, patient engagement during research development and implementation phase may provide the needed community perspective, ensure building of trust and transparency, as well as improve representation. Such analysis provides voice to the often vulnerable and unheard to improve future research and practice. Thus, researchers addressing mental health outcomes of SGM population could benefit from evaluating the cultural norms, beliefs, associated- stigma among Asian Americans related to both mental health and SGM status and how they additive impact on health outcomes. Likewise, such populations with history of trauma, such as experiences of violence, can further have heightening worsening outcomes and research that takes into account the cumulative and potentially dose-response based impact on outcomes are needed.

Furthermore, while national studies comparable to our assessment among Asian Americans are lacking, the high prevalence of abuse and suicide-related behaviors in our study population, in addition to national data noting higher rates of suicidal attempt among Asian American transgender populations, compared to their non-Asian American transgender counterparts [13], bring to attention the imperative need for violence prevention and health promotion efforts to alleviate such a burden that take into account cultural barriers in the population.

Examples of putative interventions based on the association noted in our study include cultural competency training and coordinated care that encourage cross-collaboration between public health, allied health, and healthcare systems. Here in lies the opportunity provided by the Patient Protection and Affordable Care Act of 2010, that calls for a Community Health Needs Assessment every three years by non-profit hospitals and for key interventions to be implemented based on the results of such an assessment [27]. A key opportunity here is to integrate professionals for multiple fields as well as community leaders from the Asian American and transgender communities to serve as bridges to assess the prevalence of transgender identity and needs of the transgender community, such as those related to abuse and mental health, in the service areas of such hospitals as well as to ensure targeted programs are implemented that take into account the unique barriers faced by this vulnerable group.

In addition, improving training and diversity of primary care providers can further address the barriers such populations face. For example, addressing exposure to abuse during primary care screening could further serve as the first step in ensuring suicide prevention in such a vulnerable population and our study results can inform the design of future implementation work that contributes to evidence-based practice. In recent years, many health and related professionals have enhanced their curriculum to integrate course content related to SGM health disparities [28,29]. As such, assessment of such best practices on curriculum updates and how they impact care of SGM populations may provide insight into further evidence-based practice. Further, as noted by participants in a study by Howard et al. [25], having providers of similar racial/ethnic background as well as those who respect patient’s gender identity can further serve as a critical need to improve mental health outcomes of such a vulnerable population.

Finally, the Healthy People initiative calls for the improvement of health outcomes of SGM. Yet, with the aggregation of transgender population in the often-used terminology of LGBT, most of the current empirical evidence has not disaggregated this unique population and the barriers they face. This is further coupled with the fact that very little evidence exists for Asian American transgender population, which is often attributed to cultural barriers related to discussion of mental health and sexual orientation [30,31]. As such, a national paradigm shift in research to consider transgender (T) health independent of sexual orientation (LGB) are critical to highlight the importance of addressing the barriers that transgender individuals face.

A sub-analysis of our study population also highlighted that specific gender identities within the trans spectrum have differing prevalence of abuse experiences and mental health outcomes. For example, while prevalence was high among various subgroups, trans men reported a higher prevalence of suicidal thoughts and attempts, when compared to trans women and other. Likewise, trans men had higher bathroom use related harassment as compared to the other groups. We hypothesize that potential resources for trans men support groups may be of lower availability and thus could be contributing to such outcomes. Likewise, gender queer/non-binary may not find easily accessible resources to their unique needs, including social acceptance of they/them/their pronoun, and thus have higher serious psychological distress. A current study reported differences in anxiety and depression among such groups, though results are limited to college students only [32]. These hypotheses need further testing to explore in depth the differing experiences of trans men, when compared to other gender identity, which has been preliminarily highlighted in the current literature [33].

Limitations

The results of this study should be interpreted in the context of its limitations. Cross sectional data is subject to the lack of causal or temporal relationship and longitudinal results are needed to implement life course health promotion efforts to improve mental health outcomes of the population. Likewise, such survey data is prone to recall bias and given the sensitive questions related to abuse, social desirability bias is inherent. In addition, not all potential confounders were available in this study as we were limited by availability in the data set. The potential role of acculturative stress on mental health among Asian American transgender individuals would be valuable to explore in future studies. The USTS data collection also posits some limitation to the overall study. For example, researchers have reported that some results found in surveys employing nonprobability sampling method, such as USTS, have not been replicated in their counterparts using probability sampling method, such as BRFSS [34]. However, this could be putatively attributed to social desirability bias where SGM populations maybe reluctant to disclose their status, as seen in a study in Canada [35], as well as the substantial low representation of non cis-gendered adults in such probability sample-based survey due to its reliance on random selection. Given the low prevalence of those who identify as transgender or gender non-conforming, probability sampling methods may not be ideal, without oversampling strategies, to ensure adequate representation.

Conclusion

Notwithstanding such limitations, the results of our study highlight the role of experiences of abuse and its relation to adverse mental health outcomes among one of the most vulnerable and overlooked groups: Asian American transgender individuals. Our results highlight the importance of such experiences among Asian American transgender individuals and can be used to inform how healthcare and related professionals, such as mental healthcare professionals as well as public health educators, assess the most at-risk patients. Furthermore, such results provide the foundation for healthcare and equity researchers to address the growing need for research in the area of addressing the stigmatized mental illness and needs among the population, especially those who are of SGM status.

Acknowledgments

The authors would like to acknowledge U.S. Transgender Survey for providing the data.

Data Availability

The data underlying the results presented in the study are available from the National Center for Transgender Equality (NCTE) https://www.ustranssurvey.org/data-requests.

Funding Statement

The Divisions of Intramural Research at the National Heart, Lung, and Blood Institute and the National Institutes on Minority Health and Health Disparities, National Institutes of Health provided support for this study to author ER. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

References

  • 1.National Institute of Mental Health. Mental Illness [Internet]. 2019 [cited 2020 Mar 24]. Available from: https://www.nimh.nih.gov/health/statistics/mental-illness.shtml.
  • 2.Jang Y, Yoon H, Park NS, Rhee M-K, Chiriboga DA. Mental Health Service Use and Perceived Unmet Needs for Mental Health Care in Asian Americans. Community Ment Health J. 2019. February 1;55(2):241–8. 10.1007/s10597-018-0348-3 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 3.Tung W-C. Cultural Barriers to Mental Health Services Among Asian Americans. Home Health Care Manag Pract. 2011. August 1;23(4):303–5. [Google Scholar]
  • 4.Tanap R. Why Asian-Americans and Pacific Islanders Don’t go to Therapy | NAMI: National Alliance on Mental Illness [Internet]. 2018 [cited 2019 May 29]. Available from: https://www.nami.org/Blogs/NAMI-Blog/July-2018/Why-Asian-Americans-and-Pacific-Islanders-Don-t-go.
  • 5.Kramer EJ, Kwong K, Lee E, Chung H. Cultural factors influencing the mental health of Asian Americans. West J Med. 2002. September;176(4):227–31. [PMC free article] [PubMed] [Google Scholar]
  • 6.Asian Americans/Pacific Islanders in Philanthropy. LGBTQ Asian American & Pacific Islander Communities [Internet]. Available from: https://aapip.org/sites/default/files/publication/files/lgbtq_aapi_funding_infographic_-_aapip.pdf.
  • 7.Nadal KL, Corpus MJH. “Tomboys” and “baklas”: Experiences of lesbian and gay Filipino Americans. Asian Am J Psychol. 2013;4(3):166–75. [Google Scholar]
  • 8.Ching THW, Lee SY, Chen J, So RP, Williams MT. A model of intersectional stress and trauma in Asian American sexual and gender minorities. Psychol Violence. 2018;8(6):657–68. [Google Scholar]
  • 9.Operario D, Nemoto T. Sexual risk behavior and substance use among a sample of Asian Pacific Islander transgendered women. AIDS Educ Prev Off Publ Int Soc AIDS Educ. 2005. October;17(5):430–43. 10.1521/aeap.2005.17.5.430 [DOI] [PubMed] [Google Scholar]
  • 10.American Psychological Association. Lesbian, Gay, Bisexual, Transgender [Internet]. https://www.apa.org. [cited 2019 Feb 23]. Available from: https://www.apa.org/topics/lgbt.
  • 11.Meerwijk EL, Sevelius JM. Transgender Population Size in the United States: a Meta-Regression of Population-Based Probability Samples. Am J Public Health. 2017;107(2):e1–8. 10.2105/AJPH.2016.303578 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 12.Haas AP, Eliason M, Mays VM, Mathy RM, Cochran SD, D’Augelli AR, et al. Suicide and suicide risk in lesbian, gay, bisexual, and transgender populations: review and recommendations. J Homosex. 2011;58(1):10–51. 10.1080/00918369.2011.534038 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 13.National Center for Transgender Equality. Injustice at Every Turn:A look at Asian American, South Asian, Southeast Asian, and Pacific Islander respondentsin the National Transgender Discrimination Survey [Internet]. 2012. Available from: https://transequality.org/sites/default/files/docs/resources/ntds_asianamerican_api_english.pdf.
  • 14.Mathy RM. Transgender Identity and Suicidality in a Nonclinical Sample. J Psychol Hum Sex. 2003. July 10;14(4):47–65. [Google Scholar]
  • 15.Su D, Irwin JA, Fisher C, Ramos A, Kelley M, Mendoza DAR, et al. Mental Health Disparities Within the LGBT Population: A Comparison Between Transgender and Nontransgender Individuals. Transgender Health. 2016. January 1;1(1):12–20. 10.1089/trgh.2015.0001 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 16.Reisner SL, White JM, Bradford JB, Mimiaga MJ. Transgender Health Disparities: Comparing Full Cohort and Nested Matched-Pair Study Designs in a Community Health Center. LGBT Health. 2014. September 1;1(3):177–84. 10.1089/lgbt.2014.0009 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 17.Snow A, Cerel J, Loeffler DN, Flaherty C. Barriers to Mental Health Care for Transgender and Gender-Nonconforming Adults: A Systematic Literature Review. Health Soc Work. 2019. August 2;44(3):149–55. 10.1093/hsw/hlz016 [DOI] [PubMed] [Google Scholar]
  • 18.Lombardi EL, Wilchins RA, Priesing D, Malouf D. Gender violence: transgender experiences with violence and discrimination. J Homosex. 2001;42(1):89–101. 10.1300/j082v42n01_05 [DOI] [PubMed] [Google Scholar]
  • 19.Hanna B, Desai R, Parekh T, Guirguis E, Kumar G, Sachdeva R. Psychiatric Disorders in the United States Transgender Population. Ann Epidemiol [Internet]. 2019. October 4 [cited 2019 Oct 13]; Available from: http://www.sciencedirect.com/science/article/pii/S1047279719302832. 10.1016/j.annepidem.2019.09.009 [DOI] [PubMed] [Google Scholar]
  • 20.2015 U.S. Trans Survey [Internet]. 2015 [cited 2019 May 29]. Available from: http://www.ustranssurvey.org/.
  • 21.Kessler RC, Andrews G, Colpe LJ, Hiripi E, Mroczek DK, Normand SLT, et al. Short screening scales to monitor population prevalences and trends in non-specific psychological distress. Psychol Med. 2002. August;32(6):959–76. 10.1017/s0033291702006074 [DOI] [PubMed] [Google Scholar]
  • 22.Nemoto T, Bödeker B, Iwamoto M. Social Support, Exposure to Violence and Transphobia, and Correlates of Depression Among Male-to-Female Transgender Women With a History of Sex Work. Am J Public Health. 2011. October 1;101(10):1980–8. 10.2105/AJPH.2010.197285 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 23.Testa RJ, Sciacca LM, Wang F, Hendricks ML, Goldblum P, Bradford J, et al. Effects of violence on transgender people. Prof Psychol Res Pract. 2012;43(5):452–9. [Google Scholar]
  • 24.Kristen Clements-Nolle PhD M, Rani Marx PhD M, MD MK. Attempted Suicide Among Transgender Persons. J Homosex. 2006. October 11;51(3):53–69. 10.1300/J082v51n03_04 [DOI] [PubMed] [Google Scholar]
  • 25.Howard SD, Lee KL, Nathan AG, Wenger HC, Chin MH, Cook SC. Healthcare Experiences of Transgender People of Color. J Gen Intern Med. 2019;34(10):2068–74. 10.1007/s11606-019-05179-0 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 26.Shimmin C, Wittmeier KDM, Lavoie JG, Wicklund ED, Sibley KM. Moving towards a more inclusive patient and public involvement in health research paradigm: the incorporation of a trauma-informed intersectional analysis. BMC Health Serv Res [Internet]. 2017. August 7 [cited 2020 Dec 6];17. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5547533/. 10.1186/s12913-017-2463-1 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 27.Internal Revenue Service. Requirements for 501(c)(3) Hospitals Under the Affordable Care Act–Section 501(r) [Internet]. 2018 [cited 2019 May 29]. Available from: https://www.irs.gov/charities-non-profits/charitable-organizations/requirements-for-501c3-hospitals-under-the-affordable-care-act-section-501r.
  • 28.Harvard Medical Schools increases LGBT training [Internet]. Washington Blade: Gay News, Politics, LGBT Rights. 2017 [cited 2020 Apr 24]. Available from: https://www.washingtonblade.com/2017/09/22/harvard-medical-schools-increases-lgbt-training/.
  • 29.Cohen R. Medical Students Push For More LGBT Health Training To Address Disparities [Internet]. NPR.org. 2019. [cited 2020 Apr 24]. Available from: https://www.npr.org/sections/health-shots/2019/01/20/683216767/medical-students-push-for-more-lgbt-health-training-to-address-disparities. [Google Scholar]
  • 30.Leong FTL, Kim HHW, Gupta A. Attitudes toward professional counseling among Asian-American college students: Acculturation, conceptions of mental illness, and loss of face. Asian Am J Psychol. 2011;2(2):140–53. [Google Scholar]
  • 31.Szymanski DM, Sung MR. Asian Cultural Values, Internalized Heterosexism, and Sexual Orientation Disclosure Among Asian American Sexual Minority Persons. J LGBT Issues Couns. 2013. July 1;7(3):257–73. [Google Scholar]
  • 32.Lefevor GT, Boyd-Rogers CC, Sprague BM, Janis RA. Health disparities between genderqueer, transgender, and cisgender individuals: An extension of minority stress theory. J Couns Psychol. 2019. July;66(4):385–95. 10.1037/cou0000339 [DOI] [PubMed] [Google Scholar]
  • 33.Fernández-Rouco N, Carcedo RJ, López F, Orgaz MB. Mental Health and Proximal Stressors in Transgender Men and Women. J Clin Med [Internet]. 2019. March 25 [cited 2020 Dec 6];8(3). Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6463264/. 10.3390/jcm8030413 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 34.Henderson ER, Blosnich JR, Herman JL, Meyer IH. Considerations on Sampling in Transgender Health Disparities Research. LGBT Health. 2019. September 1;6(6):267–70. 10.1089/lgbt.2019.0069 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 35.Ferlatte O, Hottes TS, Trussler T, Marchand R. Disclosure of Sexual Orientation by Gay and Bisexual Men in Government-Administered Probability Surveys. LGBT Health. 2017;4(1):68–71. 10.1089/lgbt.2016.0037 [DOI] [PubMed] [Google Scholar]

Decision Letter 0

Michelle Tye

6 Nov 2020

PONE-D-20-21733

Experiences of violence and mental health outcomes among Asian American transgender adults in the United States

PLOS ONE

Dear Dr. Becerra,

Thank you for submitting your manuscript to PLOS ONE. After careful consideration, we feel that it has merit but does not fully meet PLOS ONE’s publication criteria as it currently stands. Therefore, we invite you to submit a revised version of the manuscript that addresses the points raised during the review process.

There are a number of methodological issues to be addressed, including:

1. Please specify the number of participants included in your sample for analysis - this currently only to be provided as 7.89%

2. Please add more information on how the survey was delivered (online? face to face?), how were participants recruited? What was the eligibility criteria (who was targeted)? 

3. I have some issues with how the outcomes were defined; the  authors state that the outcome variables include dichotomized versions of suicidal ideation, suicidal thoughts, and serious psychological distress - however, only suicide thoughts are reported on (not ideation) - how do thoughts and ideation differ in this study (they usually mean the same thing)? This requires further clarification. Moreover, what instruments were used to ask participants about suicidal ideation and attempts? Were they scales, were they validated? If they were scales, I would query why the authors recoded them into dichotomous variables when a continuous score would have been clinically more significant. If authors did recode scales into dichotomous variables, how was the decision made as to what constitutes a 'yes' answer and what is a 'no' answer? Much more detail is needed. 

4. I similarly question the authors decision to create over simplistic 'yes/no' variables to assess experience of violence, when there appears to be rich data on different types of violence; there is literature to support that different types of violence have different impacts on mental health, and it would be a genuine value add of this study to examine the experience of different types of violence on suicide outcomes in this transgender population. I would strongly suggest some re analysis to provide a more nuanced understanding of the effects of types of violence on suicidal thoughts and attempts. 

Please submit your revised manuscript by Dec 20 2020 11:59PM. If you will need more time than this to complete your revisions, please reply to this message or contact the journal office at plosone@plos.org. When you're ready to submit your revision, log on to https://www.editorialmanager.com/pone/ and select the 'Submissions Needing Revision' folder to locate your manuscript file.

Please include the following items when submitting your revised manuscript:

  • A rebuttal letter that responds to each point raised by the academic editor and reviewer(s). You should upload this letter as a separate file labeled 'Response to Reviewers'.

  • A marked-up copy of your manuscript that highlights changes made to the original version. You should upload this as a separate file labeled 'Revised Manuscript with Track Changes'.

  • An unmarked version of your revised paper without tracked changes. You should upload this as a separate file labeled 'Manuscript'.

If you would like to make changes to your financial disclosure, please include your updated statement in your cover letter. Guidelines for resubmitting your figure files are available below the reviewer comments at the end of this letter.

If applicable, we recommend that you deposit your laboratory protocols in protocols.io to enhance the reproducibility of your results. Protocols.io assigns your protocol its own identifier (DOI) so that it can be cited independently in the future. For instructions see: http://journals.plos.org/plosone/s/submission-guidelines#loc-laboratory-protocols

We look forward to receiving your revised manuscript.

Kind regards,

Michelle Tye, Ph.D.

Academic Editor

PLOS ONE

Journal Requirements:

When submitting your revision, we need you to address these additional requirements.

1. Please ensure that your manuscript meets PLOS ONE's style requirements, including those for file naming. The PLOS ONE style templates can be found at

https://journals.plos.org/plosone/s/file?id=wjVg/PLOSOne_formatting_sample_main_body.pdf and

https://journals.plos.org/plosone/s/file?id=ba62/PLOSOne_formatting_sample_title_authors_affiliations.pdf

2. We note that you have indicated that data from this study are available upon request. PLOS only allows data to be available upon request if there are legal or ethical restrictions on sharing data publicly. For information on unacceptable data access restrictions, please see http://journals.plos.org/plosone/s/data-availability#loc-unacceptable-data-access-restrictions.

In your revised cover letter, please address the following prompts:

a) If there are ethical or legal restrictions on sharing a de-identified data set, please explain them in detail (e.g., data contain potentially identifying or sensitive patient information) and who has imposed them (e.g., an ethics committee). Please also provide contact information for a data access committee, ethics committee, or other institutional body to which data requests may be sent.

b) If there are no restrictions, please upload the minimal anonymized data set necessary to replicate your study findings as either Supporting Information files or to a stable, public repository and provide us with the relevant URLs, DOIs, or accession numbers. Please see http://www.bmj.com/content/340/bmj.c181.long for guidelines on how to de-identify and prepare clinical data for publication. For a list of acceptable repositories, please see http://journals.plos.org/plosone/s/data-availability#loc-recommended-repositories.

We will update your Data Availability statement on your behalf to reflect the information you provide.

3. Thank you for stating the following in the Acknowledgments Section of your manuscript:

"This work was partially supported by the Divisions of Intramural Research at the National Heart, Lung, and Blood Institute and the National Institutes on Minority Health and Health Disparities, National Institutes of Health."

We note that you have provided funding information that is not currently declared in your Funding Statement. However, funding information should not appear in the Acknowledgments section or other areas of your manuscript. We will only publish funding information present in the Funding Statement section of the online submission form.

Please remove any funding-related text from the manuscript and let us know how you would like to update your Funding Statement. Currently, your Funding Statement reads as follows:

 "The author(s) received no specific funding for this work."

Please include your amended statements within your cover letter; we will change the online submission form on your behalf.

4. Your ethics statement should only appear in the Methods section of your manuscript. If your ethics statement is written in any section besides the Methods, please move it to the Methods section and delete it from any other section. Please ensure that your ethics statement is included in your manuscript, as the ethics statement entered into the online submission form will not be published alongside your manuscript.

[Note: HTML markup is below. Please do not edit.]

Reviewers' comments:

Reviewer's Responses to Questions

Comments to the Author

1. Is the manuscript technically sound, and do the data support the conclusions?

The manuscript must describe a technically sound piece of scientific research with data that supports the conclusions. Experiments must have been conducted rigorously, with appropriate controls, replication, and sample sizes. The conclusions must be drawn appropriately based on the data presented.

Reviewer #1: Yes

Reviewer #2: Yes

**********

2. Has the statistical analysis been performed appropriately and rigorously?

Reviewer #1: Yes

Reviewer #2: Yes

**********

3. Have the authors made all data underlying the findings in their manuscript fully available?

The PLOS Data policy requires authors to make all data underlying the findings described in their manuscript fully available without restriction, with rare exception (please refer to the Data Availability Statement in the manuscript PDF file). The data should be provided as part of the manuscript or its supporting information, or deposited to a public repository. For example, in addition to summary statistics, the data points behind means, medians and variance measures should be available. If there are restrictions on publicly sharing data—e.g. participant privacy or use of data from a third party—those must be specified.

Reviewer #1: No

Reviewer #2: Yes

**********

4. Is the manuscript presented in an intelligible fashion and written in standard English?

PLOS ONE does not copyedit accepted manuscripts, so the language in submitted articles must be clear, correct, and unambiguous. Any typographical or grammatical errors should be corrected at revision, so please note any specific errors here.

Reviewer #1: Yes

Reviewer #2: Yes

**********

5. Review Comments to the Author

Please use the space provided to explain your answers to the questions above. You may also include additional comments for the author, including concerns about dual publication, research ethics, or publication ethics. (Please upload your review as an attachment if it exceeds 20,000 characters)

Reviewer #1: Experiences of violence and mental health outcomes among Asian American transgender adults in the United States

I agree that Asian American transgender individuals are an understudied population, in general, and in the context of negative mental health outcomes including suicidal ideation, suicidal thoughts, and serious psychological distress (SPD). This is novel and important work. This was a secondary data analysis of restricted-use national data.

Abstract

• Methods: can you identify how you subsetted to Asian Americans? How was this assessed in the 2015 USTS? Who is included in this ethnic group?

• Methods/Results: Improve notation for aOR and 95% CI for consistency. For example, define the format first/once in the methods then use it consistently in the results. For example:

o Methods: Adjusted odds ratio and 95% confidence interval (aOR; 95% CI) for each outcome will be adjusted for age, marital status, citizenship status, education level, employment status, and poverty level.

o Results: Experience of harassment/abuse during bathroom use had increased odds of suicidal attempts (1.81; 1.41, 2.31).

Manuscript

• Line 59-60: Does the literature refer to diagnosed cases or self-report?

• Can you speak to stigma for seeking mental health services and care?

• Line 70-71: same question as above. Does the literature refer to diagnosed cases or self-report?

• Line 96: Is the paragraph starting on this line refer to Asian Americans or transgender people nationally

• Line 155 and 164: Why is “OR” in caps?

• Line 185: Improve the statement for alpha or significance level. It is not clear what you are denoting. Perhaps you can say that “the significance level of .05 was used” or “A p-value less than 0.05 will determine a statistically significant difference”. You use other significance levels in the tables. You should mention these here as well.

• Methods/Results: as indicated for the abstract, improve notation for aOR and 95% CI for consistency. For example, define the format first/once in the methods then use it consistently in the results.

• Results: you are referring to “significantly higher “rates. Did you conduct one-tail or two tailed statistical tests? Your method section does not indicate the bivariate tests used.

• Results: Be consistent with rounding for percentages reported though this section including tables.

• Results: In tables, improve title and include sample sizes in the title or somewhere in the table. Distinguish headers from variables. Perhaps consider moving the asterisks denoting significant findings.

• Table 2: you have a symbol in front of “~U.S. Citizen” that you did not define at the footer of the table.

• Conclusion: this section lacks detail particularly to what the results indicate. what type of clinicians are your referring to? What type of assessments are your referring to?

• IRB approval: IRB review is mentioned in the acknowledgement section but not in the methods.

Reviewer #2: The manuscript, “Experiences of violence and mental health outcomes among Asian American transgender adults in the United States,” describes a study examining experiences of Asian American transgender adults in terms of violence and mental health using the 2015 US Transgender Survey. Key findings included high rates of minority stress (discrimination and abuse) as well as negative mental health outcomes, such as suicide ideation and distress. Authors highlight the need for reducing exposure to negative outcomes and greater use of trauma informed care approaches in healthcare settings. Several strengths of this study include novel topic and potential for future research. Despite several strengths, there are a number of research and conceptual issues that if addressed, would significantly improve the manuscript. These are explained below in no particular order.

1. It would be beneficial to readers to learn more about potential research on mental health of Asian American transgender and additional gender minority populations. For instance, several articles should be considered:

Ching TH, Lee SY, Chen J, So RP, Williams MT. A model of intersectional stress and trauma in Asian American sexual and gender minorities. Psychology of violence. 2018 Nov;8(6):657.

Operario D, Nemoto T. Sexual risk behavior and substance use among a sample of Asian Pacific Islander transgendered women. AIDS Education & Prevention. 2005 Oct 1;17(5):430-43.

Snow A, Cerel J, Loeffler DN, Flaherty C. Barriers to mental health care for transgender and gender-nonconforming adults: a systematic literature review. Health & social work. 2019 Aug 2;44(3):149-55.

Howard SD, Lee KL, Nathan AG, Wenger HC, Chin MH, Cook SC. Healthcare experiences of transgender people of color. Journal of general internal medicine. 2019 Oct 1;34(10):2068-74.

2. Methods: Consider providing Cronbach alpha for the Kessler-6 scale for study sample.

3. Table 2 needs a more descriptive/detailed title.

4. It appears that chi-square tests were run to test potential associations. If this represents potential prevalence by factors that are weighted, authors might consider putting the 95% Confidence Intervals

5. For logistic regression, authors may want to present findings in terms of prevalence ratios.

6. Did authors consider testing any interactions with demographics (age, education level, employment, poverty) as it appears these could represent intersectionality. Also may want to consider differences by gender identity (e.g., non-binary vs. gender male/female identifying groups).

7. It appears that additional limitations of the 2015 USTS survey were not mentioned. Authors should consider additional concerns in terms of non-probability sample. See the following for additional limitations:

Henderson, E.R., Blosnich, J.R., Herman, J.L. and Meyer, I.H., 2019. Considerations on sampling in transgender health disparities research. LGBT health, 6(6), pp.267-270.

8. The discussion needs further development, such as other studies in cisgender sexual minorities and cisgender Asian Americans with regards to experiencing abuse and risk of suicide/mental health distress.

9. Discussion should touch how healthcare needs and tailoring of trauma-informed care that considers intersectionality, such as identifying as both Asian American and a gender minority.

10. It might be helpful to readers to further tease of unique cultural concerns for Asian American gender minorities as well as details on how research can be more inclusive of these communities. It might be helpful to expand on any findings in terms of care and needed research on immigration/acculturation and gender minorities.

**********

6. PLOS authors have the option to publish the peer review history of their article (what does this mean?). If published, this will include your full peer review and any attached files.

If you choose “no”, your identity will remain anonymous but your review may still be made public.

Do you want your identity to be public for this peer review? For information about this choice, including consent withdrawal, please see our Privacy Policy.

Reviewer #1: No

Reviewer #2: Yes: Jason Flatt

[NOTE: If reviewer comments were submitted as an attachment file, they will be attached to this email and accessible via the submission site. Please log into your account, locate the manuscript record, and check for the action link "View Attachments". If this link does not appear, there are no attachment files.]

While revising your submission, please upload your figure files to the Preflight Analysis and Conversion Engine (PACE) digital diagnostic tool, https://pacev2.apexcovantage.com/. PACE helps ensure that figures meet PLOS requirements. To use PACE, you must first register as a user. Registration is free. Then, login and navigate to the UPLOAD tab, where you will find detailed instructions on how to use the tool. If you encounter any issues or have any questions when using PACE, please email PLOS at figures@plos.org. Please note that Supporting Information files do not need this step.

Attachment

Submitted filename: PONE-D-20-21733.docx

PLoS One. 2021 Mar 4;16(3):e0247812. doi: 10.1371/journal.pone.0247812.r002

Author response to Decision Letter 0


15 Dec 2020

Response to reviews:

Thank you for the comprehensive feedback that allows our manuscript to be improved. We have addressed each of the comments below, added content in the manuscript/tables, and have marked them as track changes as well. We have bolded the responses below for ease of finding.

Review 1

1. It would be beneficial to readers to learn more about potential research on mental health of Asian American transgender and additional gender minority populations. For instance, several articles should be considered:

Ching TH, Lee SY, Chen J, So RP, Williams MT. A model of intersectional stress and trauma in Asian American sexual and gender minorities. Psychology of violence. 2018 Nov;8(6):657.

Operario D, Nemoto T. Sexual risk behavior and substance use among a sample of Asian Pacific Islander transgendered women. AIDS Education & Prevention. 2005 Oct 1;17(5):430-43.

Snow A, Cerel J, Loeffler DN, Flaherty C. Barriers to mental health care for transgender and gender-nonconforming adults: a systematic literature review. Health & social work. 2019 Aug 2;44(3):149-55.

Howard SD, Lee KL, Nathan AG, Wenger HC, Chin MH, Cook SC. Healthcare experiences of transgender people of color. Journal of general internal medicine. 2019 Oct 1;34(10):2068-74.

Response: Our second paragraph addressed the current literature (peer-reviewed and others) on mental health burden Asian American sexual and gender minorities. We have further expanded it by including additional references from those noted above. They have been included in the introduction section (Ching et al., Operaio and Nemoto, Snow et al.) as well as in the discussion section (Howard et al.), in addition to a few others.

2. Methods: Consider providing Cronbach alpha for the Kessler-6 scale for study sample.

Response: The Cronbach alpha of .89 has been added in the methods section.

3. Table 2 needs a more descriptive/detailed title.

Response: We have added a more descriptive title that provides details on the context (including analysis) of the table results.

4. It appears that chi-square tests were run to test potential associations. If this represents potential prevalence by factors that are weighted, authors might consider putting the 95% Confidence Intervals

Response: The weights applied in this study were used to reduce bias for demographic representation. Since this was a non-probability sample, confidence intervals may not be an appropriate measure of reliability since their estimates are inherently biased from non-random sampling. We have stated the limitations of a non-probability sample in our discussion.

5. For logistic regression, authors may want to present findings in terms of prevalence ratios.

Response: We did consider reporting prevalence ratio, but during the literature review, we noted that majority of the studies used odds ratio. In order to be utilized for comparison purposes, as well as putative meta analysis by other researchers, we wanted to remain consistent. The interpretation, however, does provide better context on the data.

6. Did authors consider testing any interactions with demographics (age, education level, employment, poverty) as it appears these could represent intersectionality. Also may want to consider differences by gender identity (e.g., non-binary vs. gender male/female identifying groups).

Response: We checked interactions for based on relevant literature and it is noted in the methods. Survey participants were informed that “trans” or “transgender” is defined as all trans and non-binary identities for the purposes of the survey. As such, the data is inclusive of the different identities. However, per the recommendation, we have added a sub-analysis in our study as part of Tables 4 and 5.

7. It appears that additional limitations of the 2015 USTS survey were not mentioned. Authors should consider additional concerns in terms of nonprobability sample. See the following for additional limitations:

Henderson, E.R., Blosnich, J.R., Herman, J.L. and Meyer, I.H., 2019. Considerations on sampling in transgender health disparities research. LGBT health, 6(6), pp.267-270.

Response: We have included content from this study as well as additional to address the limitations.

8. The discussion needs further development, such as other studies in cisgender sexual minorities and cisgender Asian Americans with regards to experiencing abuse and risk of suicide/mental health distress.

Response: We included cisgender focused studies in introduction and discussion, but limited to ensure the focus remains on the need for such among the SGM population, especially Asian Americans transgender populations.

9. Discussion should touch how healthcare needs and tailoring of trauma-informed care that considers intersectionality, such as identifying as both Asian American and a gender minority.

Response: We have added context related to such analysis in the discussion along with the following comment’s content as well.

10. It might be helpful to readers to further tease of unique cultural concerns for Asian American gender minorities as well as details on how research can be more inclusive of these communities. It might be helpful to expand on any findings in terms of care and needed research on immigration/acculturation and gender minorities.

Response: We have added context related to addressing the unique cultural factors in the discussion.

Review 2

1. Please specify the number of participants included in your sample for analysis - this currently only to be provided as 7.89%

Response: We have added the sample in the results section.

2. Please add more information on how the survey was delivered (online? face to face?), how were participants recruited? What was the eligibility criteria (who was targeted)?

Response: This has been added in the data source section of the methods.

3. I have some issues with how the outcomes were defined; the authors state that the outcome variables include dichotomized versions of suicidal ideation, suicidal thoughts, and serious psychological distress - however, only suicide thoughts are reported on (not ideation) - how do thoughts and ideation differ in this study (they usually mean the same thing)? This requires further clarification.

Moreover, what instruments were used to ask participants about suicidal ideation and attempts? Were they scales, were they validated? If they were scales, I would query why the authors recoded them into dichotomous variables when a continuous score would have been clinically more significant. If authors did recode scales into dichotomous variables, how was the decision made as to what constitutes a 'yes' answer and what is a 'no' answer? Much more detail is needed.

Response: We agree that more detailed content would be valuable. However, the USTS data provides the dichotomized variables as utilized in this study and others. However, the information on instruments for suicidal thoughts, suicidal attempts, and SPD, are added in the measures section.

4. I similarly question the authors decision to create over simplistic 'yes/no' variables to assess experience of violence, when there appears to be rich data on different types of violence; there is literature to support that different types of violence have different impacts on mental health, and it would be a genuine value add of this study to examine the experience of different types of violence on suicide outcomes in this transgender population. I would strongly suggest some re analysis to provide a more nuanced understanding of the effects of types of violence on suicidal thoughts and attempts.

Response: USTS has four types of abuses included: past year verbal harassment, past year physical attack, past year unwanted sexual contact, and ever experience of unwanted sexual contact. While we acknowledge that verbal versus physical versus sexual can have differing outcomes, our goal was to explore any experiences of violence and thus we categorized them as any abuse. With a larger sample size, further disaggregation may be of value. However, we did add additional types of abuse, including partner and harassment during bathroom use.

Attachment

Submitted filename: Response to Reviewers-12-6-2020.docx

Decision Letter 1

Michelle Tye

11 Jan 2021

PONE-D-20-21733R1

Experiences of violence and mental health outcomes among Asian American transgender adults in the United States

PLOS ONE

Dear Dr. Becerra,

Thank you for submitting your manuscript to PLOS ONE. After careful consideration, we feel that it has merit but does not fully meet PLOS ONE’s publication criteria as it currently stands. Therefore, we invite you to submit a revised version of the manuscript that addresses the points raised during the review process.

==============================

The authors have adequately addressed the first set of revisions, there are some additional queries below that need to be addressed, and which should significantly strengthen the manuscript. 

==============================

Please submit your revised manuscript by Feb 25 2021 11:59PM. If you will need more time than this to complete your revisions, please reply to this message or contact the journal office at plosone@plos.org. When you're ready to submit your revision, log on to https://www.editorialmanager.com/pone/ and select the 'Submissions Needing Revision' folder to locate your manuscript file.

Please include the following items when submitting your revised manuscript:

  • A rebuttal letter that responds to each point raised by the academic editor and reviewer(s). You should upload this letter as a separate file labeled 'Response to Reviewers'.

  • A marked-up copy of your manuscript that highlights changes made to the original version. You should upload this as a separate file labeled 'Revised Manuscript with Track Changes'.

  • An unmarked version of your revised paper without tracked changes. You should upload this as a separate file labeled 'Manuscript'.

If you would like to make changes to your financial disclosure, please include your updated statement in your cover letter. Guidelines for resubmitting your figure files are available below the reviewer comments at the end of this letter.

If applicable, we recommend that you deposit your laboratory protocols in protocols.io to enhance the reproducibility of your results. Protocols.io assigns your protocol its own identifier (DOI) so that it can be cited independently in the future. For instructions see: http://journals.plos.org/plosone/s/submission-guidelines#loc-laboratory-protocols

We look forward to receiving your revised manuscript.

Kind regards,

Michelle Tye, Ph.D.

Academic Editor

PLOS ONE

[Note: HTML markup is below. Please do not edit.]

Reviewers' comments:

Reviewer's Responses to Questions

Comments to the Author

1. If the authors have adequately addressed your comments raised in a previous round of review and you feel that this manuscript is now acceptable for publication, you may indicate that here to bypass the “Comments to the Author” section, enter your conflict of interest statement in the “Confidential to Editor” section, and submit your "Accept" recommendation.

Reviewer #1: (No Response)

**********

2. Is the manuscript technically sound, and do the data support the conclusions?

The manuscript must describe a technically sound piece of scientific research with data that supports the conclusions. Experiments must have been conducted rigorously, with appropriate controls, replication, and sample sizes. The conclusions must be drawn appropriately based on the data presented.

Reviewer #1: Yes

**********

3. Has the statistical analysis been performed appropriately and rigorously?

Reviewer #1: I Don't Know

**********

4. Have the authors made all data underlying the findings in their manuscript fully available?

The PLOS Data policy requires authors to make all data underlying the findings described in their manuscript fully available without restriction, with rare exception (please refer to the Data Availability Statement in the manuscript PDF file). The data should be provided as part of the manuscript or its supporting information, or deposited to a public repository. For example, in addition to summary statistics, the data points behind means, medians and variance measures should be available. If there are restrictions on publicly sharing data—e.g. participant privacy or use of data from a third party—those must be specified.

Reviewer #1: Yes

**********

5. Is the manuscript presented in an intelligible fashion and written in standard English?

PLOS ONE does not copyedit accepted manuscripts, so the language in submitted articles must be clear, correct, and unambiguous. Any typographical or grammatical errors should be corrected at revision, so please note any specific errors here.

Reviewer #1: Yes

**********

6. Review Comments to the Author

Please use the space provided to explain your answers to the questions above. You may also include additional comments for the author, including concerns about dual publication, research ethics, or publication ethics. (Please upload your review as an attachment if it exceeds 20,000 characters)

Reviewer #1: I agree that Asian American transgender individuals are an understudied population, in general, and in the context of negative mental health outcomes including suicidal ideation, suicidal thoughts, and serious psychological distress (SPD). This is novel and important work. This was a secondary data analysis of restricted-use national data.

Abstract

• Methods: Can you identify how you subsetted to Asian Americans? How was this assessed in the 2015 USTS? Who is included in this ethnic group?

• Methods/Results: Improve notation for aOR and 95% CI for consistency. For example, define the format first/once in the methods then use it consistently in the results. For example:

o Methods: Adjusted odds ratio and 95% confidence interval (aOR; 95% CI) for each outcome will be adjusted for age, marital status, citizenship status, education level, employment status, and poverty level.

o Results: Experience of harassment/abuse during bathroom use had increased odds of suicidal attempts (aOR: 1.81; 95% CI: 1.41, 2.31).

Manuscript

• Line 59-60: Does the literature refer to diagnosed cases or self-report?

• Can you speak to stigma for seeking mental health services and care?

• Line 70-72: same question as above. Does the literature refer to diagnosed cases or self-report?

• Line 155 and 157: Why is “OR” in caps? Perhaps consider listing the measures without stating the entire question asked, separated with semicolons. For example, instead of “In the past year, did anyone verbally harass you for any reason?”, you can indicate “verbal harassment for any reason in past year”.

• Line 211: Improve the statement for alpha or significance level. It is not clear what you are denoting. Perhaps you can say that “The significance level of .05 was used” or “A p-value less than 0.05 determined a statistically significant difference”. You use other significance levels in the tables. You should mention these here as well.

• Methods/Results: as indicated for the abstract, improve notation for aOR and 95% CI for consistency. For example, define the format first/once in the methods then use it consistently in the results.

• Results: you are referring to “significantly higher “rates. Did you conduct one-tail or two tailed statistical tests? Your method section does not indicate the bivariate tests used (Line 200).

• Results: Be consistent with rounding for percentages reported though this section including tables.

• Results: In tables, improve title and include sample sizes in the title or somewhere in the table. Distinguish headers from variables. Perhaps consider moving the asterisks denoting significant findings.

• Tables: Consider justifying to the right for the numeric columns.

• Table 2: You have a symbol in front of “~U.S. Citizen” that you did not define at the footer of the table.

• Conclusion: this section lacks detail particularly to what the results indicate. What type of clinicians are your referring to? What type of assessments are your referring to?

**********

7. PLOS authors have the option to publish the peer review history of their article (what does this mean?). If published, this will include your full peer review and any attached files.

If you choose “no”, your identity will remain anonymous but your review may still be made public.

Do you want your identity to be public for this peer review? For information about this choice, including consent withdrawal, please see our Privacy Policy.

Reviewer #1: No

[NOTE: If reviewer comments were submitted as an attachment file, they will be attached to this email and accessible via the submission site. Please log into your account, locate the manuscript record, and check for the action link "View Attachments". If this link does not appear, there are no attachment files.]

While revising your submission, please upload your figure files to the Preflight Analysis and Conversion Engine (PACE) digital diagnostic tool, https://pacev2.apexcovantage.com/. PACE helps ensure that figures meet PLOS requirements. To use PACE, you must first register as a user. Registration is free. Then, login and navigate to the UPLOAD tab, where you will find detailed instructions on how to use the tool. If you encounter any issues or have any questions when using PACE, please email PLOS at figures@plos.org. Please note that Supporting Information files do not need this step.

PLoS One. 2021 Mar 4;16(3):e0247812. doi: 10.1371/journal.pone.0247812.r004

Author response to Decision Letter 1


10 Feb 2021

Response to reviews:

Thank you for the reviews of our manuscript. We have addressed all the reviews and responses are noted below in bold, for ease of finding.

Abstract

• Methods: Can you identify how you subsetted to Asian Americans? How was this assessed in the 2015 USTS? Who is included in this ethnic group?

Response: We included this in the methods section of the manuscript, instead of abstract, to ensure we remain within the word limit. However, we added a statement to clarify it was census defined as well.

• Methods/Results: Improve notation for aOR and 95% CI for consistency. For example, define the format first/once in the methods then use it consistently in the results. For example:

o Methods: Adjusted odds ratio and 95% confidence interval (aOR; 95% CI) for each outcome will be adjusted for age, marital status, citizenship status, education level, employment status, and poverty level.

o Results: Experience of harassment/abuse during bathroom use had increased odds of suicidal attempts (aOR: 1.81; 95% CI: 1.41, 2.31).

Response: We have updated the methods section in the abstract accordingly.

We have updated the results section as well to be consistent and note aOR in each case.

Manuscript

• Line 59-60: Does the literature refer to diagnosed cases or self-report?

• Can you speak to stigma for seeking mental health services and care?

• Line 70-72: same question as above. Does the literature refer to diagnosed cases or self-report?

Response: This has been updated in the instruction section. We also added the importance of addressing stigma in the conclusion.

• Line 155 and 157: Why is “OR” in caps? Perhaps consider listing the measures without stating the entire question asked, separated with semicolons. For example, instead of “In the past year, did anyone verbally harass you for any reason?”, you can indicate “verbal harassment for any reason in past year”.

Response: In the previous revision cycle, we were asked to list the full question. However, we have updated the structure to read with more ease and not capitalized the OR.

• Line 211: Improve the statement for alpha or significance level. It is not clear what you are denoting. Perhaps you can say that “The significance level of .05 was used” or “A p-value less than 0.05 determined a statistically significant difference”. You use other significance levels in the tables. You should mention these here as well.

Response: We’ve updated this section to read more clearly as well as add the .01 and .001 mentioned in the tables.

• Methods/Results: as indicated for the abstract, improve notation for aOR and 95% CI for consistency. For example, define the format first/once in the methods then use it consistently in the results.

Response: We have updated to be consistent and note aOR in each case.

• Results: you are referring to “significantly higher “rates. Did you conduct one-tail or two tailed statistical tests? Your method section does not indicate the bivariate tests used (Line 200).

Response: We added a statement on using two-tailed in the data analysis section of the methods. We also added survey-weighted chi-square for bivariate analysis in the methods section.

• Results: Be consistent with rounding for percentages reported though this section including tables.

Response: We have updated to remain consistent.

• Results: In tables, improve title and include sample sizes in the title or somewhere in the table. Distinguish headers from variables. Perhaps consider moving the asterisks denoting significant findings.

Response: We have updated the tables though moving the asterisks may not reflect the significance of the cell. However, we have tabbed the variables to make it more clear.

• Tables: Consider justifying to the right for the numeric columns.

Response: They have been updated to be justified to the right.

• Table 2: You have a symbol in front of “~U.S. Citizen” that you did not define at the footer of the table.

Response: This was a typo that has been now deleted.

• Conclusion: this section lacks detail particularly to what the results indicate. What type of clinicians are your referring to? What type of assessments are your referring to?

Response: We have updated the conclusion to clarify these items.

Attachment

Submitted filename: Response to Reviewers-2-8-2021.docx

Decision Letter 2

Michelle Tye

16 Feb 2021

Experiences of violence and mental health outcomes among Asian American transgender adults in the United States

PONE-D-20-21733R2

Dear Dr. Becerra,

We’re pleased to inform you that your manuscript has been judged scientifically suitable for publication and will be formally accepted for publication once it meets all outstanding technical requirements.

Within one week, you’ll receive an e-mail detailing the required amendments. When these have been addressed, you’ll receive a formal acceptance letter and your manuscript will be scheduled for publication.

An invoice for payment will follow shortly after the formal acceptance. To ensure an efficient process, please log into Editorial Manager at http://www.editorialmanager.com/pone/, click the 'Update My Information' link at the top of the page, and double check that your user information is up-to-date. If you have any billing related questions, please contact our Author Billing department directly at authorbilling@plos.org.

If your institution or institutions have a press office, please notify them about your upcoming paper to help maximize its impact. If they’ll be preparing press materials, please inform our press team as soon as possible -- no later than 48 hours after receiving the formal acceptance. Your manuscript will remain under strict press embargo until 2 pm Eastern Time on the date of publication. For more information, please contact onepress@plos.org.

Kind regards,

Michelle Tye, Ph.D.

Academic Editor

PLOS ONE

Additional Editor Comments (optional):

Reviewers' comments:

Acceptance letter

Michelle Tye

23 Feb 2021

PONE-D-20-21733R2

Experiences of violence and mental health outcomes among Asian American transgender adults in the United States.

Dear Dr. Becerra:

I'm pleased to inform you that your manuscript has been deemed suitable for publication in PLOS ONE. Congratulations! Your manuscript is now with our production department.

If your institution or institutions have a press office, please let them know about your upcoming paper now to help maximize its impact. If they'll be preparing press materials, please inform our press team within the next 48 hours. Your manuscript will remain under strict press embargo until 2 pm Eastern Time on the date of publication. For more information please contact onepress@plos.org.

If we can help with anything else, please email us at plosone@plos.org.

Thank you for submitting your work to PLOS ONE and supporting open access.

Kind regards,

PLOS ONE Editorial Office Staff

on behalf of

Dr. Michelle Tye

Academic Editor

PLOS ONE

Associated Data

    This section collects any data citations, data availability statements, or supplementary materials included in this article.

    Supplementary Materials

    Attachment

    Submitted filename: PONE-D-20-21733.docx

    Attachment

    Submitted filename: Response to Reviewers-12-6-2020.docx

    Attachment

    Submitted filename: Response to Reviewers-2-8-2021.docx

    Data Availability Statement

    The data underlying the results presented in the study are available from the National Center for Transgender Equality (NCTE) https://www.ustranssurvey.org/data-requests.


    Articles from PLoS ONE are provided here courtesy of PLOS

    RESOURCES