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. 2021 Mar 5;38(3):624–634. doi: 10.1007/s11814-020-0719-7

Cyclodextrin-mediated gold nanoparticles as multisensing probe for the selective detection of hydroxychloroquine drug

Jaise Mariya George 1, Beena Mathew 1,✉
PMCID: PMC7935477  PMID: 33716372

Abstract

β-Cyclodextrin (β-CD) modified gold nanoparticles (AuNP) were rapidly synthesized using microwave assisted procedure. Parameters, such as time, pH and concentrations of β-CD and gold, were optimized for the synthesis of β-CD-AuNP. The addition of enantiomers and racemic mixture of hydroxychloroquine (R-HCQ, S-HCQ and RS-HCQ) drugs and their interaction with β-CD led to a red shift in the surface plasmon resonance of β-CD-AuNP. The changes associated with the introduction of HCQ in β-CD-AuNP were studied using various characterization techniques such as UV-vis, FT-IR, XRD, dynamic light scattering, zeta potential, transmission electron microscopy, fluorescence spectroscopy and electrochemical techniques. The host-guest interaction of β-cyclodextrin with S-HCQ, R-HCQ and RS-HCQ resulted in the aggregation of gold nanoparticles. The surface plasmon resonance at 521 nm for β-CD-AuNP was shifted to 600, 620 and 670 nm on the addition of S-HCQ, R-HCQ and RS-HCQ, respectively, with a color change from pink to blue. The selectivity and sensitivity of the developed system for RS-HCQ were investigated and the limit of detection (LOD=3 s/m) was found to be 2.61, 0.15, and 0.85 nM for optical, fluorescence and electrochemical methods, respectively. The successful monitoring of RS-HCQ drug in pharmaceutical samples is possible with these techniques.

Electronic Supplementary Material

Supplementary material is available for this article at 10.1007/s11814-020-0719-7 and is accessible for authorized users.

Keywords: Gold Nanoparticles, β-Cyclodextrin, Hydroxy Chloroquine, Enantiomeric, Sensing

Acknowledgements

JMG gratefully acknowledges University Grants Commission (UGC), for the award of research fellowship, and Department of Science & Technology (DST), Government of India for instrumentation facilities by DST-PURSE Phase II.

Supporting Information

11814_2020_719_MOESM1_ESM.pdf (551.9KB, pdf)

Cyclodextrin-mediated gold nanoparticles as multisensing probe for the selective detection of hydroxychloroquine drug

Footnotes

Conflict of Interest

We have no conflict of interest to declare.

Supporting Information

Additional information as noted in the text. This information is available via the Internet at http://www.springer.com/chemistry/journal/11814.

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