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. 2021 Mar 7;113(3):1219–1233. doi: 10.1016/j.ygeno.2021.01.026

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Fig. S5 — Monocytes may regulate the proliferation and exhaustion of T cells during disease course

Heatmap showed the predicted ligand activity and the regulatory potential of the ligand and their target genes. A. Ligands of CD14⁺ Mono2, CD16⁺ Mono, CD24⁺ Mono, HLA-DR⁺ Mono and LDHB⁺ Mono and their target genes in CD8⁺ Te cells in the acute stage compared with healthy controls (HCs).

B. Ligands of CD14⁺ Mono2, CD16⁺ Mono and their target genes in CD4⁺ Tn cells in the recovery stage compared with HCs. C. Ligands of CD14⁺ Mono2, CD16⁺ Mono and their target genes in CD8⁺ Tn cells in the stable stage versus healthy controls (orange: ligand; purple: target genes). D. Ligands of CD14⁺ Mono2, CD16⁺ Mono and their target genes in CD8⁺ Tn cells in the recovery stage compared with HCs.