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. Author manuscript; available in PMC: 2021 Mar 7.
Published in final edited form as: Bone. 2015 Aug 28;81:562–572. doi: 10.1016/j.bone.2015.08.021

Figure 1.

Figure 1.

Mechanical properties as assessed by three-point bending of femora collected from female C57BL/6J mice (77-days-old at euthanasia). Mice were assigned to one of five groups (n=12/group): Baseline, Ground Control with Vehicle (phosphate-buffered saline), Ground Control with Osteoprotegerin (OPG-Fc; 20 mg/kg), Spaceflight with Vehicle, and Spaceflight with OPG-Fc. The duration of microgravity exposure during spaceflight was 12 days. Data are presented at mean ± SEM. 2-way-ANOVA differences are presented. Significant differences within Loading (Ground Control vs. Spaceflight) or Drug (Vehicle vs. OPG-Fc) were tested by a Tukey follow-up test (significance set at P<0.05). Loading (L) indicates a significant difference between Ground Control and Spaceflight within Vehicle or OPG-Fc; Drug (D) indicates a significant difference between Vehicle and OPG-Fc within Ground Control or Spaceflight.