Table 1.
Effect of the pretreatment of Morus alba extract on the frequency of micronucleated erythrocytes in cyclophosphamide treated animals.
| Bone Marrow Micronucleus Test |
Control |
M. alba (1 g/kg) |
Cyclophosphamide (CP-75 mg) |
M. alba (0.25 g/kg) + CP |
M. alba (0.5 g/kg) + CP |
M. alba (1 g/kg) + CP |
α-Toco (50 mg) + CP |
|---|---|---|---|---|---|---|---|
| Micronuclei in PCE (%) | 0.52 ± 0.02 | 0.55 ± 0.04 | 1.09 ± 0.07 a | 1.03 ± 0.02 | 1.01 ± 0.02* | 1.00 ± 0.02** | 0.96 ± 0.02*** |
| Micronuclei in NCE (%) | 0.49 ± 0.02 | 0.50 ± 0.02 | 1.74 ± 0.19 a | 1.58 ± 0.04 | 1.55 ± 0.02 * | 1.49 ± 0.02 ** | 1.42 ± 0.02 *** |
| P/N Ratio | 1.05 ± 0.04 | 0.99 ± 0.04 | 0.62 ± 0.04 a | 0.60 ± 0.02 | 0.55 ± 0.02 * | 0.53 ± 0.02 ** | 0.49 ± 0.02 *** |
(P.S: M. alba—Morus alba, CP—cyclophosphamide, α-toco—α-tocopherol); values are represented as Mean ± SD, N=6. Statistics: one-way ANOVA followed by Bonferroni; a p < 0.001 compared with control, * p < 0.05, ** p < 0.01, *** p < 0.001 compared with cyclophosphamide group.