Abstract
A 27-year-old man presented with developmental disorders in the maxillary incisors and asymmetric smile. Differential diagnosis between geminated and fused maxillary central incisors was conducted using cone-beam computed tomography (CBCT). The complexities of root canal system was handled using suitable shaping instruments and ultrasonic activation tips. Root apexes were sealed with mineral trioxide aggregate plugs. The anterior maxillary gingiva was surgically recontoured, and CAD/CAM Zirconia crowns were placed after the gingival healing phase. The combination of the 3D radiological examination, the clinical screening, and the use of a diagnostic wax-up presented a successful approach to manage this rare clinical case.
1. Introduction
Gemination is a malformation of a single tooth during its development to form a completely or partially separated crown with a single root [1]. The union of two or more teeth that normally develops separately is referred as fusion [2]. Gemination exhibits a normal number of teeth, whilst fusion presents a reduced number within the dental arch [3]. The clinical management of teeth with gemination or fusion may present difficulties since the size/shape of the crown deteriorates the aesthetic appearance, and the root canal morphology complicates the endodontic treatment [4].
Visualizing the internal anatomy of roots to obtain sufficient details about their surroundings is critical to achieve successful endodontic treatment [5]. The use of the standard two-dimensional radiographic technologies exhibits a limitation for the localization and characterization of complex root canal systems [6]. The application of cone-beam computed tomography (CBCT) has been revealed to be beneficial for endodontic treatment, particularly in understanding the complicated root canal morphology of fused/geminated teeth [7–9]. The flowing report describes multidisciplinary approach to restore the function and the esthetics appearance of both fused and geminated maxillary central incisors with the aid of CBCT.
2. Case Presentation
A 27-year-old male patient was referred to the Department of Conservative Dentistry and Endodontics with developmental disorders in the maxillary incisors and asymmetric smile. The clinical examination revealed an abnormal morphology of teeth #11 and #21. The absence of #12 and the presence of tooth #22 suggested the probability of fusion between #11 and #12 and a gemination in #21 (Figure 1). All vital signs were found to be normal. The teeth were not sensitive to palpation or percussion. The mobility of the teeth was within the normal limits. Periodontal probing using PCP-UNC 15 probe (Hu-Friedy, Leimen, Germany) showed no periodontal pocketing around the teeth. The two-dimensional radiographic examination (Figure 2) showed a complex pulp structure with no periodontal ligament space around the teeth. CBCT images were obtained using Vatech Pax-Duo3D Pano/CBCT (Vatech™, Seoul, South Korea) unit. CBCT images were reconstructed in three dimensions (3D) using Ez3D-I software (Vatech™, Seoul, South Korea). The CBCT images (Figure 3) revealed separated pulp chambers in the coronal third of #21, then a fusion of both root canals. The teeth #11 and #12 showed a separation under 1 mm of the cemento-enamel junction in the CBCT images (Figure 4).
Figure 1.

Preoperative image presenting geminated (arrow) and fused maxillary central incisors (dashed arrow).
Figure 2.

(a) Initial radiograph of tooth #21 before the endodontic intervention. (b) Radiograph of tooth #21 after the endodontic treatment, with the set of the 3 mm apical plugs of MTA.
Figure 3.

Plane of axial CBCT sections of maxillary showing fusion between #11 and #12 and a gemination in #21. The gemination presents a separated pulp chambers and merging root canals (arrow).
Figure 4.

Plane of coronal CBCT sections of maxillary showing the separation level of the fused #11 and #12 (arrow).
In this case, the correction of the shape/size of the anterior maxillary teeth would be conducted using fixed prosthesis after crown sectioning and preparation. The potential exposure of pulp chamber of both central incisors indicated the need for root canal treatment, which was conducted before crown preparation and restoration. A diagnostic waxed-up was made (Figure 5), and a mock-up was tried in vivo. The treatment plan was discussed thoroughly with the patient, and a written informed consent was obtained.
Figure 5.

Initial wax-up showing the size/shape of the teeth. A new gingival level was placed.
Anesthesia was administrated, and a rubber dam was applied. Root canals were prepared and shaped using XP-endo Shaper (FKG Dentaire, La Chaux-de-Fonds, Switzerland). Root canals were fully irrigated with 2.5% sodium hypochlorite (NaOCl) and activated using Sonofile K-file tips #25 (Satelec Acteon, Merignac Cedex, France) mounted in a P5 Booster ultrasonic scaler (Satelec Acteon). Apexes were sealed with 3 mm apical MTA (mineral trioxide aggregate) plugs (Dentsply Tulsa Dental, Tulsa, OK, USA). After 24 hours, resin-based sealer (Tgadeal, Technical, and General LTD London) was used with warm gutta-percha (BeeFill 2 in 1, VDW, Munich, Germany) for back-filling (Figure 2). Then, GIC restoration (Fuji IX, GC, Tokyo, Japan) was placed.
A session was set after 2 weeks of the endodontic obturation to recontour the anterior maxillary gingiva. The gingival pocket was 3.5 mm when measured; thus, there was no need for bone crest modification, and the cutting was within 1 mm. The patient returned for the next session after 2 weeks with a completely healed gingiva. The crowns of the anterior maxillary teeth from tooth #13 to tooth #23 were prepared for reshaping and smile correcting according to the cast module analysis. Crown cores were fabricated from zirconia blocks (Vita Zahnfabrik, Bad Säckingen, Germany) using CAD-CAM (computer-aided design and computer-aided manufacturing) system (Roland DWX-52® 5-Axis, California, USA), then gingival color modifiers were added to mimic the surrounding gingiva. The posttreatment photograph with final result is presented in Figure 6.
Figure 6.

Posttreatment photograph with final result.
3. Discussion and Conclusion
Dental fusion is the union of two or more dental germs [10]. The fusion maybe a complete or incomplete depending upon stage of teeth development at the time of merging [10]. Such abnormality might be confused with gemination, since gemination is an abnormal development of a tooth separating the crown into two, while sharing a common root [11]. Gemination is the result of a single tooth bud division attempt [12]. Fusion can be differentiated from gemination by the count of teeth within a dental arch and have the number being reduced in fusion whilst remaining normal in gemination [4, 13–15]. In this report, a case of a partially fused central incisor to lateral incisor is presented in the upper right arch. In the upper left arch, however, the number of teeth is normal, and differentiation from gemination is impossible. The differentiation between gemination and fusion may not be critically significant for the clinical treatment [16].
In the dental literature, different clinical approaches are advocated to manage fused/geminated teeth. Those approaches include orthodontic treatment, tooth extraction, reduction of crown size followed by restoration, sectioning of the fused teeth, and no treatment [17].
The developmental anomaly in this clinical case was associated with appearance disapproval and social apprehension, reported by the patient. Therefore, a significant alternation in the teeth shape, size, and proportion was required to achieve a satisfied outcome.
The diagnosis/treatment of fused teeth is intractable. High-resolution 3-dimensional imaging has been demonstrated to be superior to periapical radiography in vitro and in vivo, particularly for canal identification and characterization of internal and external root morphology [18, 19]. In this report, the CBCT images helped in having a 3-dimensional view of the root systems, establishing the fact of having a partial or complete fusion, thus offering the best protocol for endodontic treatment. Wax-up and mock-up revealed the best treatment choices available and enabled the patient to see the expected results before initiating the treatment.
Endodontic treatment was conducted in this case as a significant modification in the incisors' shape was required for esthetic reason. Periodic clinical follow-up is of utmost importance to ascertain the long-term success of the endodontic therapy [20]. The main limitation of the technique used in the management of the present case is that it was not minimally invasive. Esthetic reshaping of anterior teeth required a considerable removal of tooth substance. However, the selection of monolithic zirconia helped in reducing tooth structure loss [21].
Periodic periodontal assessment and treatment are essential for the success of indirect fixed dental prostheses [22]. Different variables affect significantly the prognosis of the treated teeth including oral rinsing solutions, toothbrushing technique, and motivation in self-performed plaque control [23–25].
In conclusion, careful case diagnosis and a precise treatment plan are obligated for the successful management of such rare case. A three-dimensional CBCT introduced valuable information about root canal systems and their surroundings which contributed substantially to the success of the endodontic therapy and case management.
Data Availability
The data that support the findings of this study are available from the corresponding author upon reasonable request.
Ethical Approval
This experimental protocol was approved by the Ethics Committee of Damascus University. The protocol version number is No. 2020-10.
Consent
Informed consent was obtained from the patient. Written informed consent was obtained from the patient before the study.
Conflicts of Interest
The authors deny any conflicts of interest related to this paper.
References
- 1.Braun A., Appel T., Frentzen M. Endodontic and surgical treatment of a geminated maxillary incisor. International Endodontic Journal. 2003;36(5):380–386. doi: 10.1046/j.1365-2591.2003.00668.x. [DOI] [PubMed] [Google Scholar]
- 2.Bernardi S., Bianchi S., Bernardi G., et al. Clinical management of fusion in primary mandibular incisors: a systematic literature review. Acta Odontologica Scandinavica. 2020;78(6):417–424. doi: 10.1080/00016357.2020.1734233. [DOI] [PubMed] [Google Scholar]
- 3.Grammatopoulos E. Gemination or fusion? British Dental Journal. 2007;203(3):119–120. doi: 10.1038/bdj.2007.699. [DOI] [PubMed] [Google Scholar]
- 4.Tsesis I., Steinbock N., Rosenberg E., Kaufman A. Y. Endodontic treatment of developmental anomalies in posterior teeth: treatment of geminated/fused teeth–report of two cases. International Endodontic Journal. 2003;36(5):372–379. doi: 10.1046/j.1365-2591.2003.00666.x. [DOI] [PubMed] [Google Scholar]
- 5.Vertucci F. J. Root canal morphology and its relationship to endodontic procedures. Endodontic Topics. 2005;10(1):3–29. doi: 10.1111/j.1601-1546.2005.00129.x. [DOI] [Google Scholar]
- 6.Patel S., Dawood A., Ford T. P., Whaites E. The potential applications of cone beam computed tomography in the management of endodontic problems. International Endodontic Journal. 2007;40(10):818–830. doi: 10.1111/j.1365-2591.2007.01299.x. [DOI] [PubMed] [Google Scholar]
- 7.Hegde S., Ajila V., Kamath J. S., Babu S., Pillai D. S., Nair S. M. Importance of cone-beam computed tomography in dentistry: an update. SRM J Res Dent Sci. 2018;9(4):p. 186. doi: 10.4103/srmjrds.srmjrds_26_18. [DOI] [Google Scholar]
- 8.Rabiee H., McDonald N. J., Jacobs R., Aminlari A., Inglehart M. R. Endodontics program directors’, residents’, and endodontists’ considerations about CBCT-related graduate education. Journal of Dental Education. 2018;82(9):989–999. doi: 10.21815/JDE.018.098. [DOI] [PubMed] [Google Scholar]
- 9.Mensch K., Simonffy L., Dombi C., et al. Endodontic and microsurgical treatments of maxillary lateral incisor dens invaginatus in combination with cone-beam-computed tomography fusion imaging. Oral Radiology. 2017;33(2):147–152. doi: 10.1007/s11282-016-0257-5. [DOI] [Google Scholar]
- 10.Ballal S., Sachdeva G. S., Kandaswamy D. Endodontic management of a fused mandibular second molar and paramolar with the aid of spiral computed tomography: a case report. Journal of Endodontia. 2007;33(10):1247–1251. doi: 10.1016/j.joen.2007.06.021. [DOI] [PubMed] [Google Scholar]
- 11.Gupta S., Goel M., Dutta S. Synodontia between permanent maxillary lateral incisor and a supernumerary tooth: surgical treatment perspective. Journal of Oral Health and Community Dentistry. 2007;1(3):52–55. doi: 10.5005/johcd-1-3-52. [DOI] [Google Scholar]
- 12.Gadimli C., Sari Z. Interdisciplinary treatment of a fused lower premolar with supernumerary tooth. Eur J Dent. 2011;5(3):349–353. [PMC free article] [PubMed] [Google Scholar]
- 13.Miri S. S., Ghorbani H., Mohassel A. R. Endodontic treatment of fused teeth with talon cusp. Case Reports in Dentistry. 2014;2014:4. doi: 10.1155/2014/738185.738185 [DOI] [PMC free article] [PubMed] [Google Scholar]
- 14.Rajendran R. Developmental disturbances of oral and paraoral structures. Shafer's textbook of oral pathology. 2006;5:3–112. [Google Scholar]
- 15.Neville B. W., Damm D. D., Allen C. M., Chi A. C. Oral and Maxillofacial Pathology. Elsevier Health Sciences; 2015. [Google Scholar]
- 16.KIM E., JOU Y. A supernumerary tooth fused to the facial surface of a maxillary permanent central incisor: case report. Journal of Endodontia. 2000;26(1):45–48. doi: 10.1097/00004770-200001000-00012. [DOI] [PubMed] [Google Scholar]
- 17.Kremeier K., Hülsmann M. Fusion and gemination of teeth: review of the literature, treatment considerations, and report of cases. ENDO. 2007;1(2):111–123. [Google Scholar]
- 18.Mashyakhy M., Chourasia H. R., Jabali A., Almutairi A., Gambarini G. Analysis of fused rooted maxillary first and second molars with merged and C-shaped canal configurations: prevalence, characteristics, and correlations in a Saudi Arabian population. Journal of Endodontia. 2019;45(10):1209–1218. doi: 10.1016/j.joen.2019.06.009. [DOI] [PubMed] [Google Scholar]
- 19.Wu L., Shi B., Zhang R., Liu J. Case report root canal therapy of a supernumerary tooth fused with maxillary second molar: a case report. International Journal of Clinical and Experimental Medicine. 2019;12(4):4422–4427. [Google Scholar]
- 20.Sailer I., Makarov N. A., Thoma D. S., Zwahlen M., Pjetursson B. E. All-ceramic or metal-ceramic tooth-supported fixed dental prostheses (FDPs)? A systematic review of the survival and complication rates. Part I: single crowns (SCs) Dental Materials. 2015;31(6):603–623. doi: 10.1016/j.dental.2015.02.011. [DOI] [PubMed] [Google Scholar]
- 21.Schwindling F. S., Waldecker M., Rammelsberg P., Rues S., Bömicke W. Tooth substance removal for ceramic single crown materials—an in vitro comparison. Clinical Oral Investigations. 2019;23(8):3359–3366. doi: 10.1007/s00784-018-2753-y. [DOI] [PubMed] [Google Scholar]
- 22.Ercoli C., Caton J. G. Dental prostheses and tooth-related factors. Journal of Periodontology. 2018;89(S):223–236. doi: 10.1002/JPER.16-0569. [DOI] [PubMed] [Google Scholar]
- 23.Butera A., Gallo S., Maiorani C., et al. Probiotic alternative to chlorhexidine in periodontal therapy: evaluation of clinical and microbiological parameters. Microorganisms. 2021;9(1):p. 69. doi: 10.3390/microorganisms9010069. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 24.Muniz F. W. M. G., Cavagni J., Langa G. P. J., Stewart B., Malheiros Z., Rösing C. K. A systematic review of the effect of oral rinsing with H2O2 on clinical and microbiological parameters related to plaque, gingivitis, and microbes. International Journal of Dentistry. 2020;2020:18. doi: 10.1155/2020/8841722.8841722 [DOI] [PMC free article] [PubMed] [Google Scholar]
- 25.Yamada M., Hino S., Nakamura S., Iijima Y., Kaneko T., Horie N. Accidental oral injuries by electric toothbrush: a report of three cases. Case Reports in Dentistry. 2020;2020:4. doi: 10.1155/2020/8819850. [DOI] [PMC free article] [PubMed] [Google Scholar]
Associated Data
This section collects any data citations, data availability statements, or supplementary materials included in this article.
Data Availability Statement
The data that support the findings of this study are available from the corresponding author upon reasonable request.
