Table 1.
Magnetic resonance imaging protocol
| 3D T1-w MPRAGEa | 3D T2-w | PD-w | DWIb | GRASE | rs-fMRI | |
|---|---|---|---|---|---|---|
| Resolution acquired/reconstructed (mm2) | 1 × 1/1 × 1 | 1 × 1/0.8 × 0.8 | 0.99 × 1/0.98 × 0.98 | 2.24 × 2.24/2 × 2 | 0.99 × 2.04/0.96 × 0.95 | 3 × 3/3 × 3 |
| Slice thickness acquired/reconstructed (mm) | 1/1 | 1.6/0.8 | 1/1 | 2.20/2.20 | 5/2.5 | 3/3 |
| Number of reconstructed slices | 170 | 200 | 170 | 70 | 40 | 36 |
| Field of view ap/rl/fh (mm) | 256 × 200 × 170 | 256 × 160 × 256 | 250 × 170 × 250 | 224 × 224 × 154 | 230 × 190 × 100 | 240 × 240 × 143 |
| Orientation | Transverse | Sagittal | Sagittal | Transverse | Transverse | Transverse |
| Echo time (ms) | 3.5 | 363 | 30 | 60 | 8, 16, 24 … 384 | 30 |
| Repetition time (ms) | 1800 | 2500 | 3000 | 7.1 | 1073 | 2000 |
| Flip angle (deg) | 8 | 90 | 90 | 90 | 90 | 90 |
| Acquisition time (min) | 6:34 | 4:43 | 10:33 | 7:27 | 7:30 | 5:00 |
| Purpose | Anatomical reference | WMH quantification | WMH quantification | White matter integrity quantification | Myelin quantification | Functional connectivity assessment |
ap anterior-posterior, rl right left, fh foot-head
aAdditional sequence parameters for 3D T1-w MPRAGE: inversion time = 810 ms
bAdditional sequence parameters for DWI: 60 gradient directions at b = 700 s/mm2, 1 unweighted scan