Table 1.

Reported non-necroptosis functions of MLKL and its role in several specific diseases

Disease	Cell type	RIPK3 activation	MLKL phosphorylation	MLKL oligomerization	Phenotype	Function	Reference
Type 2 diabetes	Hepatocyte	+	+	+	Insulin resistance	Inhibiting PIP3 production	86
Non-alcoholic fatty liver disease	Hepatocyte	-	+	+	Hepatocellular injury	Suppressing autophagic flux	87
Listeria monocytogenes infection	Intestine epithelial cell	+	+	-	Slow-multiplying bacterial states of Listeria in epithelial cells	Impinging on bacterium to disrupt their plasma membranes	11
Multiple sclerosis	Oligodendrocyte	-	+	Unknown	Increased demyelination	Unknown	13
Nerve regeneration	Schwann cell	-	+	Unknown	Increased demyelination	Loss of the myelin structure maintenance function of sulfatide	12
Nasopharyngeal carcinoma	Radioresistant nasopharyngeal cell	-	-	Unknown	Irradiation-induced invasion	Promoting epithelial-mesenchymal transition	14
Loss of the pregnancy	Syncytiotrophoblast	-	-	Unknown	Release of dangerous proteins	Facilitating endosomal trafficking and generation of extracellular vesicles	94