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Utilization of fully-humanized ncRNA carriers to achieve in vivo fermentation production of biologic RNAi agents. (A) Substituting miR-34a duplexes within the htRNA/hsa-pre-miR-34a carrier with target miRNA or siRNA offers humanized RNAi agents or hBERAs. (B and C) Two sets of target hBERAs were all highly expressed in bacteria, using either htRNALeu/hsa-pre-miR-34a or htRNASer/hsa-pre-miR-34a as a carrier. Total RNA from wild type E. coli was used for comparison.
