Fig. 3.

Self-renewal of liver sinusoidal endothelial cells. LSEC are highly plastic and can self-renew upon different challenges. Resident LSEC progenitors have a unique molecular signature expressing CD157 and ABC transporters. CD157-positive LSEC are self-renewable and can replenish the liver microvasculature following challenge. In addition to resident LSEC progenitors, BM-derived progenitor cells may be recruited to the liver and contribute to the regenerating liver vasculature following severe, resident EC damaging challenge such as irradiation-induced vascular injury.