Figure 1.

Ablation of striatal Rgs7 in mice results in an antidepressant-like phenotype. A, Representative Western blottings and graphs of densitometry values for Rgs7 levels in the striatum of WT and Rgs7 sKO mice (n = 4/genotype). B, Scheme of behavioral tests. WT and Rgs7 sKO mice were tested in (C) marble burying (MB), (D) elevated plus maze (EPM), (E) tail suspension test (TST), and (F) forced swim test (FST) (n = 10/genotype). Data shown as mean ± SEM; *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001.