Onychopapilloma Presenting as Erythronychia and Leukonychia: Dermoscopic Features of Two Cases in Korea

Dear Editor:

Onychopapilloma is an idiopathic benign neoplasm of the nail matrix and nail bed¹. It is a relatively new nail tumor as the term “onychopapilloma” was first established in 2000 by Baran and Perrin¹. To date, less than 100 cases have been reported in the literature². It typically presents as longitudinal erthronychia extending from the lunula to the distal nail. However, clinical diagnosis is often challenging because it frequently resembles other conditions. The majority of cases were reported in Western countries. Reports in Asia have been rare. To our knowledge, only two reports from Korea have been published³,⁴.

A 62-year-old woman with distal red streaks on her left thumbnail was referred for evaluation. The lesion, which was mildly tender, was noted 15 years prior. On physical examination, a 2-mm longitudinal erythronychia was localized on the distal left thumb. Dermoscopy revealed a homogeneous whitish band from the lunula edge with distal splinter hemorrhages (Fig. 1A). Nail edge dermoscopy showed a localized distal subungual keratosis at the hyponychium (Fig. 1B). Histopathologic examination of excisional biopsy specimen showed an elongated digitating papillomatous acanthotic epidermis, with the superficial layer displaying keratinous zone and ample eosinophilic cytoplasm (Fig. 2). These findings were consistent for onychopapilloma.

Fig. 1. (A) Dermoscopy of the nail plate showing homogeneous white bands with splinter hemorrhages (inset: clinical image). (B) Nail edge dermoscopy revealing a 2-mm subungual keratotic mass. (C) Dermoscopy of the nail plate showing V-shaped longitudinal leukonychia extending from the distal lunula border to the free edge of the nail plate. Splinter hemorrhages present with distal onycholytic change (inset: clinical image). (D) Nail edge dermoscopy disclosing a 4-mm hyperkeratotic mass lifting the nail plate at the hyponychium.

Fig. 2. Histopathologic examination revealing digitating papillomatosis and acanthosis of the nail bed and hyponychia. Features of keratogenous zone at the nail bed indicative of matrix metaplasia (H&E: A, ×40; B, ×200; C, ×100).

Our second case was a 59-year-old woman who presented with a 1-year history of yellowish discoloration and distal onycholysis of the right fifth fingernail. Dermoscopy showed a V-shaped yellowish band extending from the lunula border to the free edge of the nail plate (Fig. 1C). Splinter hemorrhages were present. Nail edge dermoscopy revealed a hyperkeratotic mass lifting the nail plate (Fig. 1D). We received the patient;s consent form about publishing all photographic materials. Histopathologic findings revealed acanthosis and hyperkeratosis with the upper layers of the nail bed containing eosinophilic cytoplasm of which were compatible with onychopapilloma (Supplementary Fig. 1).

Baran and Perrin first reported the condition in 1995 as “localized multinucleate distal subungual keratosis.”⁵ The term was later replaced with “onychopapilloma” following the histopathologic review of cases with a lack of multinucleate cells in the majority¹. Reports on onychopapilloma are limited in the Asian population. In addition to the rarity of this disease, its unfamiliarity may be contributory to the lack of reported cases in Asia.

Onychopapilloma classically presents as localized longitudinal erythronychia, leukonychia, melanonychia, or splinter hemorrhage². Dermoscopy enables clinicians to observe the detailed morphology of subtle changes within the lesion. Dermoscopic findings of onychopapilloma were recently reported as red bands, keratotic subungual masses, and splinter hemorrhages². In both our cases, dermoscopy following initial inspection provided further detailed description of morphologic changes due to onychopapilloma. Both cases disclosed white or yellow homogenous bands, splinter hemorrhages, and keratotic subungual masses. The bands were not longitudinal. Although the pathogenesis of onychopapilloma is not fully understood, it is thought to affect the distal matrix²,³.Therefore, we propose that band sparing of the proximal nail is a distinguishing trait of onychopapilloma.

In conclusion, we report two rare cases of onychopapilloma, which occurred in Asia. Dermoscopic assessment of subtle changes of the nail and its margins facilitates the recognition of onychopapilloma in the clinical setting.

SUPPLEMENTARY MATERIALS

Supplementary data can be found via http://anndermatol.org/src/sm/ad-30-742-s001.pdf.

Supplementary Fig. 1

(A) Gross view of a white keratotic mass partially lifted with the distal nail plate. (B) Excisional biopsy specimen showing acanthosis with eosinophilic cytoplasm of upper layers of the nail bed (H&E, ×100). Yellow arrow indicating the keratinous zone of the nail matrix.