Table 3.
Sex-specific miRNAs with lower expression in placental tissue in newborn girls compared to boys, top 35 miRNAs, ranked based on their significance. Mean log2 miRNA expression in both or separated sexes with variances are provided
| miRNA | Mean log2 expression (overall) | Variance (overall) | Mean log2 expression (boys) | Variance (boys) | Mean log2 expression (girls) | Variance (girls) | β regr. coefficient | P-value | FDR |
|---|---|---|---|---|---|---|---|---|---|
| hsa-miR-4646-5p | 2.08 | 0.31 | 2.30 | 0.29 | 1.85 | 0.22 | −0.47 | 4.65E-04 | 2.68E-02 |
| hsa-miR-4793-5p | 2.46 | 0.22 | 2.67 | 0.22 | 2.25 | 0.14 | −0.37 | 4.97E-04 | 2.68E-02 |
| hsa-miR-6778-5p | 2.39 | 0.58 | 2.69 | 0.59 | 2.03 | 0.36 | −0.62 | 5.92E-04 | 2.68E-02 |
| hsa-miR-7107-5p | 4.33 | 0.42 | 4.61 | 0.43 | 4.06 | 0.27 | −0.55 | 6.78E-04 | 2.68E-02 |
| hsa-miR-1915-3p | 5.87 | 0.64 | 6.22 | 0.77 | 5.52 | 0.28 | −0.63 | 8.09E-04 | 2.68E-02 |
| hsa-miR-663a | 2.72 | 0.89 | 3.10 | 0.84 | 2.34 | 0.67 | −0.76 | 1.34E-03 | 2.86E-02 |
| hsa-miR-575 | 3.69 | 0.47 | 3.96 | 0.51 | 3.41 | 0.29 | −0.55 | 1.48E-03 | 2.86E-02 |
| hsa-miR-6757-5p | 1.74 | 0.51 | 2.03 | 0.63 | 1.42 | 0.20 | −0.54 | 1.50E-03 | 2.86E-02 |
| hsa-miR-3141 | 2.50 | 0.30 | 2.71 | 0.30 | 2.29 | 0.23 | −0.42 | 2.25E-03 | 3.04E-02 |
| hsa-miR-6727-5p | 3.99 | 0.63 | 4.28 | 0.85 | 3.69 | 0.27 | −0.61 | 2.54E-03 | 3.04E-02 |
| hsa-miR-1207-5p | 5.73 | 0.58 | 6.02 | 0.70 | 5.44 | 0.31 | −0.58 | 2.57E-03 | 3.04E-02 |
| hsa-miR-1225-5p | 6.40 | 0.51 | 6.68 | 0.56 | 6.11 | 0.32 | −0.54 | 2.58E-03 | 3.04E-02 |
| hsa-miR-4298 | 2.69 | 0.37 | 2.91 | 0.47 | 2.46 | 0.17 | −0.47 | 2.67E-03 | 3.04E-02 |
| hsa-miR-4281 | 6.79 | 0.62 | 7.09 | 0.79 | 6.49 | 0.30 | −0.60 | 2.81E-03 | 3.04E-02 |
| hsa-miR-7847-3p | 2.93 | 0.32 | 3.14 | 0.39 | 2.72 | 0.17 | −0.43 | 3.02E-03 | 3.04E-02 |
| hsa-miR-6510-5p | 2.98 | 0.46 | 3.23 | 0.49 | 2.72 | 0.31 | −0.51 | 3.18E-03 | 3.04E-02 |
| hsa-miR-6775-5p | 3.31 | 0.43 | 3.57 | 0.51 | 3.05 | 0.22 | −0.47 | 3.24E-03 | 3.04E-02 |
| hsa-miR-6800-5p | 5.83 | 0.73 | 6.16 | 0.94 | 5.49 | 0.32 | −0.63 | 3.31E-03 | 3.04E-02 |
| hsa-miR-6803-5p | 5.42 | 0.55 | 5.73 | 0.58 | 5.11 | 0.34 | −0.50 | 3.35E-03 | 3.04E-02 |
| hsa-miR-4530 | 6.56 | 0.69 | 6.90 | 0.78 | 6.22 | 0.38 | −0.55 | 3.37E-03 | 3.04E-02 |
| hsa-miR-4741 | 5.76 | 0.49 | 6.01 | 0.41 | 5.50 | 0.45 | −0.52 | 3.51E-03 | 3.04E-02 |
| hsa-miR-4800-5p | 3.02 | 0.43 | 3.28 | 0.45 | 2.76 | 0.27 | −0.47 | 3.53E-03 | 3.04E-02 |
| hsa-miR-6867-5p | 2.39 | 0.29 | 2.54 | 0.33 | 2.21 | 0.18 | −0.40 | 3.57E-03 | 3.04E-02 |
| hsa-miR-4516 | 9.85 | 1.57 | 10.32 | 1.62 | 9.39 | 1.13 | −0.93 | 3.64E-03 | 3.04E-02 |
| hsa-miR-619-5p | 2.31 | 0.69 | 2.63 | 0.74 | 2.00 | 0.46 | −0.61 | 3.66E-03 | 3.04E-02 |
| hsa-miR-6087 | 8.39 | 1.52 | 8.86 | 1.96 | 7.92 | 0.67 | −0.89 | 3.81E-03 | 3.04E-02 |
| hsa-miR-4669 | 3.30 | 0.18 | 3.46 | 0.19 | 3.13 | 0.12 | −0.29 | 4.36E-03 | 3.25E-02 |
| hsa-miR-4299 | 7.64 | 0.74 | 7.94 | 0.87 | 7.34 | 0.44 | −0.62 | 4.50E-03 | 3.32E-02 |
| hsa-miR-6768-5p | 2.79 | 1.10 | 3.16 | 1.23 | 2.42 | 0.72 | −0.75 | 4.82E-03 | 3.48E-02 |
| hsa-miR-1972 | 1.92 | 0.60 | 2.20 | 0.68 | 1.58 | 0.31 | −0.49 | 5.04E-03 | 3.50E-02 |
| hsa-miR-371a-5p | 3.38 | 0.59 | 3.65 | 0.59 | 3.12 | 0.47 | −0.55 | 5.12E-03 | 3.51E-02 |
| hsa-miR-4505 | 5.54 | 0.85 | 5.88 | 1.18 | 5.19 | 0.31 | −0.62 | 5.28E-03 | 3.56E-02 |
| hsa-miR-6088 | 5.54 | 0.36 | 5.79 | 0.40 | 5.29 | 0.21 | −0.39 | 5.41E-03 | 3.59E-02 |
| hsa-miR-6858-5p | 3.85 | 0.97 | 4.19 | 0.93 | 3.50 | 0.81 | −0.69 | 5.63E-03 | 3.65E-02 |
| hsa-miR-4739 | 6.59 | 1.84 | 7.06 | 2.12 | 6.11 | 1.16 | −0.95 | 5.99E-03 | 3.74E-02 |