FIG. 8.

Survival and growth of Pax8KO mice. (A) Survival curves of Pax8KO mice treated with T4, T3, or T4+T3 compared with Pax8Het controls. (B) Neonatal growth. (C, D) Postweaning growth in TH-treated Pax8KO males (C) and females (D). “abcd” indicate p < 0.01 vs. Pax8Het controls, Pax8KO+T4, and Pax8KO+T3+T4, respectively, as determined by ANOVA and Fisher's LSD test. ***Indicates p < 0.001 vs. all other groups as determined by a log-rank Mantel–Cox test. (Note that only two Pax8KO+T3 mice, both males, survived to 12 weeks of age). NS, none survived.