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. 2021 Feb 25;11(3):349. doi: 10.3390/biom11030349

Figure 5.

Figure 5

Roles of syndecan-2 in promoting and inhibiting angiogenesis. (a) Syndecan-2-VEGFA165-VEGFR2 tricomplex promotes angiogenesis. Heparan sulfate chains present in syndecan-2 associate to VEGFA165 through a heparin binding domain (HBD) increasing its local concentration and enhancing the binding to its receptor VEGFR2 (b) Syndecan-2 shedding inhibits angiogenesis. Shed syndecan-2 binds to CD148 which promotes the reduction of β1-integrin activity in endothelial cells. The inactivation of β1-integrin reduces cell migration and consequently inhibits angiogenesis.