Table 2.
The mean concentration (pg/mL) of each target present in culture supernatants was determined using individual protein standards for each of the 4 patient (4898, 4836, 2780, and 5178) experiments. Secretion of all other factors remained unchanged (Table S3).
| Cytokine/Chemokine Concentration (pg/mL) | ||||
|---|---|---|---|---|
| IFNγ | ||||
| 4898 | 4836 | 2780 | 5178 | |
| T cells Only | <0.53 | 212.47 | 113.23 | 3.32 |
| + Explants | 0.62 | 105.40 | 150.66 | 1.55 |
| + Explants/Mφ | 1.13 | 18.65 | 209.30 | 78.56 |
| TNFα | ||||
| 4898 | 4836 | 2780 | 5178 | |
| T cells Only | <1.20 | 1.21 | 1.71 | 3.52 |
| + Explants | <1.20 | <1.20 | 1.95 | <1.20 |
| + Explants/Mφ | <1.20 | <1.20 | 1.58 | 1.58 |
| IL-10 | ||||
| 4898 | 4836 | 2780 | 5178 | |
| T cells Only | <1.09 | 1.675 | 1.18 | 1.77 |
| + Explants | 2.95 | 3.44 | 3.96 | 2.74 |
| + Explants/Mφ | 1.73 | 17.03 | 8.12 | 8.31 |
| Arginase | ||||
| 4898 | 4836 | 2780 | 5178 | |
| T cells Only | 3663.90 | 3923.90 | 2346.75 | 3975.41 |
| + Explants | 3052.86 | 3285.92 | 2346.46 | 2819.79 |
| + Explants/Mφ | 5712.62 | 4302.11 | 4212.98 | 5670.56 |