Table 2.
The Hardy–Weinberg equilibrium p-values and distribution of genotype frequencies of VDR gene variants in patients with postmenopausal osteoporosis and control.
| Gene Variant | Genotype | PMO n = 355 |
CON n = 247 |
OR (95% CI) | Adjusted OR (95% CI) 1 | ||
|---|---|---|---|---|---|---|---|
| % | HWE | % | HWE | ||||
| rs7975232 | C/C | 23.7 | 0.17 | 31.2 | 0.7 | Ref. | Ref. |
| C/A | 45.9 | 48.2 | 1.3 (0.9–1.9) | 1.3 (0.8–2.1) | |||
| A/A | 30.4 | 20.6 | 1.9 (1.2–3.1) * | 2.1 (1.3–3.6) * | |||
| rs1544410 | C/C | 25.4 | 0.24 | 36.4 | 0.6 | Ref. | Ref. |
| C/T | 46.7 | 46.6 | 1.5 (0.9–2.1) | 1.6 (1.0–2.4) * | |||
| T/T | 27.9 | 17.0 | 2.4 (1.5–3.8) ** | 2.1 (1.2–3.6) * | |||
| rs731236 | A/A | 24.2 | 0.4 | 37.2 | 0.51 | Ref. | Ref. |
| A/G | 47.6 | 45.8 | 1.6 (1.1–2.3) ** | 2.1 (1.3–3.3) ** | |||
| G/G | 28.2 | 17.0 | 2.6 (1.6–4.1) ** | 2.3 (1.4–4.0) ** | |||
| rs2228570 | G/G | 27.9 | 0.17 | 26.7 | 1.0 | Ref. | Ref. |
| A/G | 46.2 | 50.2 | 0.9 (0.6–1.3) | 0.9 (0.6–1.5) | |||
| A/A | 25.9 | 23.1 | 1.1 (0.7–1.7) | 1.0 (0.6–1.8) | |||
| rs11568820 | C/C | 69.0 | 0.02 | 66.4 | 0.68 | Ref. | Ref. |
| C/T | 30.1 | 29.6 | 0.9 (0.6–1.3) | 1.2 (0.8–1.8) | |||
| T/T | 0.9 | 4.0 | 0.2 (0.1–0.7) | 0.2 (0.1–1.0) | |||
| C/T+T/T 2 | 31.0 | 33.6 | 0.8 (0.6–1.3) | 1.1 (0.7–1.6) | |||
PMO, postmenopausal osteoporosis; CON, control; HWE, Hardy–Weinberg equilibrium; OR, odds ratio; CI, confidence interval; Ref., referent value; * p FDR < 0.05, ** p FDR < 0.01; 1 Adjusted by confounding factors (BMI); 2 Dominant model of inheritance used due to low minor allele frequency. The values highlighted in bold indicate a significant association.