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. 2021 Mar 15;13(3):388. doi: 10.3390/pharmaceutics13030388

Figure 3.

Figure 3

Inhibitory effects of P-gp inhibitors on BCRP-mediated efflux of mitoxantrone in Caco-2 cells. The Papp,AB (●), and Papp,BA (▲) values were determined by the AP-to-BL and BL-to-AP transport of mitoxantrone in Caco-2 cells in the presence or absence of various concentrations of P-gp inhibitors. The Papp,BA values of mitoxantrone in the presence of GF120918, LY335979, and WK-X-34 were cited from our previous report [31]. Data are represented as mean ± S.D. for three experiments using different wells from a single passage of Caco-2 cells.