Table A5.
Gene ontology (GO) that define biological function. The GO annotations, accompanied by evidence-based statements describe specific gene product and specific ontology term (biological function). g-profile enrichment terms obtained from positive and negative values of 18 CpGs selected from BECon on overal survival by LASSO procedure. All the data have p value low than 0.05. MF: molecular function, CC: cellular component, BP: biological process.
| Source | Term_NAME | Term_id | Adjusted_p_Value | Negative_log10_of _Adjusted_p_Value | Direction Coefficient |
|---|---|---|---|---|---|
| GO:MF | glycosaminoglycan binding | GO:0005539 | 0.008788287085578 | 2.05609576449095 | Negative |
| GO:CC | collagen-containing extracellular matrix | GO:0062023 | 0.048474322092945 | 1.31448825575832 | Negative |
| KEGG | ECM-receptor interaction | KEGG:04512 | 0.037233188408127 | 1.42906977203396 | Negative |
| CORUM | CD44-LRP1 complex | CORUM:7535 | 0.049698019554143 | 1.30366091738024 | Negative |
| GO:MF | growth hormone secretagogue receptor activity | GO:0001616 | 0.049775611543161 | 1.3029833955258 | Positive |
| GO:BP | regulation of neurotransmitter receptor localization to postsynaptic specialization membrane | GO:0098696 | 0.000167004924934 | 3.77727072142761 | Positive |
| GO:BP | regulation of receptor localization to synapse | GO:1902683 | 0.001168645063196 | 2.93231737121765 | Positive |
| GO:BP | protein localization to postsynaptic specialization membrane | GO:0099633 | 0.001335544908879 | 2.8743415038609 | Positive |
| GO:BP | neurotransmitter receptor localization to postsynaptic specialization membrane | GO:0099645 | 0.001335544908879 | 2.8743415038609 | Positive |
| GO:BP | regulation of protein localization to synapse | GO:1902473 | 0.003070843427737 | 2.51274232624767 | Positive |
| GO:BP | protein localization to postsynaptic membrane | GO:1903539 | 0.007006418620425 | 2.15450391795907 | Positive |
| GO:BP | protein localization to postsynapse | GO:0062237 | 0.009117775996435 | 2.04011108165666 | Positive |
| GO:BP | response to dexamethasone | GO:0071548 | 0.009117775996435 | 2.04011108165666 | Positive |
| GO:BP | regulation of postsynaptic membrane neurotransmitter receptor levels | GO:0099072 | 0.013616524667261 | 1.86593372285098 | Positive |
| GO:BP | receptor localization to synapse | GO:0097120 | 0.013616524667261 | 1.86593372285098 | Positive |
| GO:BP | protein localization to synapse | GO:0035418 | 0.033345288657273 | 1.47696551870962 | Positive |