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. 2021 Mar 11;11(3):418. doi: 10.3390/biom11030418

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Effect of dopamine receptor antagonists on 7-hydroxy-2-dipropylaminotetralin (7-OH-DPAT)-induced vasoconstriction, in aortic segments isolated from wild-type (WT, A,C) and D3R⁻/⁻ mice (B,D). (A,B) Effect of the D3R antagonist SB-277011-A; (C,D) effect of the D2R antagonist L741,626. Each curve (with vertical bars representing standard errors) represents the average from 8–10 preparations. Two-way ANOVA, Panel A (antagonist conc.: F_(2,84) = 7.23, p = 0.0013; agonist conc.: F_(6,84) = 26.41, p < 0.0001; antagonist conc. x agonist conc. F_(12,84) = 2.50, p = 0.0076); Panel C (antagonist conc.: F_(2,105) = 3.53, p = 0.033; agonist conc.: F_(6,105) = 26.80, p < 0.0001); Panel A (antagonist conc.: F_(2,84) = 7.23, p = 0.0013; agonist conc.: F_(6,84) = 26.41, p < 0.0001; antagonist conc. × agonist conc. F_(12,105) = 1.16, p = 0.3163) and Bonferroni’s test (* p < 0.05, ** p < 0.01 vs. control).