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Representative mechanism of TRPV1 receptors regulation by PPARα. (A) TRPV1 channels stimulation induced by agonists. Phosphorylation of TRPV1 (indicated as P in yellow circles) is known to be a cellular event promoting the channel activity (B) The activation of PPARα by PEA or canonical agonists, suppresses TRPV1 activity, making the channels refractory to stimuli.
