Table 3.
Hematological parameters of male Balb/c mice exposed to high LMM6 concentration in acute toxicity assessment.
| Hematological Parameters | Analyzed Groups | ||||
|---|---|---|---|---|---|
| Healthy | IP Control | IV Control | IP LMM6 | IV LMM6 | |
| Total RBC (106/mm3) | 8.39 ± 0.53 | 8.96 ± 0.92 | 9.13 ± 0.32 | 8.96 ± 0.58 | 8.31 ± 1.28 |
| Haematocrit (%) | 43.66 ± 0.58 | 45 ± 1 | 45.5 ± 1 | 44.43 ± 0.53 | 46 ± 0 |
| Hemoglobin (g/dL) | 21.48 ± 0.64 | 20.31 ± 0.40 | 20.90 ± 0.69 | 20.65 ± 0.58 | 21.01 ± 0.21 |
| MCV (fL) | 52.15 ± 3.08 | 50.31 ± 5.11 | 49.86 ± 0.98 | 49.77 ± 3.67 | 53.46 ± 3.40 |
| MCH (pg) | 25.64 ± 1.15 | 22.83 ± 2.06 | 22.89 ± 0.46 | 23.05 ± 1.49 | 24.02 ± 1.44 |
| MCHC (%) | 49.21 ± 1.83 | 44.88 ± 0.50 * | 45.92 ± 0.73 * | 46.49 ± 1.37 * | 45.27 ± 1.03 * |
| Platelet (103/mm3) | 355.66 ± 71.28 | 570.00 ± 125.79 * | 406.00 ± 42.68 | 402.71 ± 48.33 | 394.00 ± 77.24 |
Hematological parameters were determined following 14 days exposure to LMM6 in single dose. Abbreviations; Healthy: normal mice; IP control: treated intraperitoneally with the vehicle; IV control: treated intravenous with the vehicle; IP LMM6: treated with 50 mg/kg of LMM6 intraperitoneally; IV LMM6: treated with 25 mg/kg of LMM6 intravenous. RBC: Red blood cells; MCV: mean corpuscular volume; MCH: mean corpuscular hemoglobin; MCHC: mean corpuscular hemoglobin concentration. Values represent the mean ± SD. * p < 0.05, statistically significant changes compared with healthy control.