Table 4.
Differential count of peripheral blood leukocytes of male Balb/c mice exposure to high LMM6 concentration in acute toxicity assessment.
| Groups | Leukogram | |||||
|---|---|---|---|---|---|---|
| Leukocytes | Neutrophils | Monocytes | Lymphocytes | Eosinophils | Basophils | |
| 103/mm3 | % (103/mm3) | |||||
| Healthy | 4.5 ± 1.9 | 18 ± 4.36 (0.83 ± 0.62) |
1 ± 1 (0.05 ± 0.05) |
78.66 ± 5.14 (3.52 ± 1.47) |
2.33 ± 0.58 (0.11 ± 0.06) |
- |
| IP control | 7.9 ± 2.0 | 17.25 ± 1.70 (1.36 ± 0.35) |
0.5 ± 1 (0.04 ± 0.09) |
80 ± 3.74 (6.37 ± 1.82) |
2.25 ± 1.5 (0.16 ± 0.12) |
- |
| IV control | 10.0 ± 2.6 * | 20 ± 3.91 (2.05 ±0.77) |
0.5 ± 0.58 (0.05 ± 0.06) |
77.75 ± 4.19 (7.77 ± 2.02) |
1.75 ± 1.5 (0.15 ± 0.12) |
- |
| IP LMM6 | 5.4 ± 2.4 | 18.14 ± 4.45 (1.06 ± 0.62) |
1 ± 0.63 (0.06 ± 0.06) |
78.86 ± 4.88 (4.21 ± 1.70) |
2.14 ± 1.21 (0.11 ± 0.11) |
- |
| IV LMM6 | 6.0 ± 1.9 | 19.66 ± 2.94 (1.14 ± 0.25) |
0.66 ± 0.51 (0.05 ± 0.04) |
77.66 ± 2.16 (4.71 ± 1.65) |
2 ± 0.82 (0.13 ± 0.08) |
- |
Differential count of peripheral blood leukocytes was realized following 14 days exposure to LMM6 in single dose. Abbreviations; Healthy: normal mice; IP control: treated intraperitoneally with the vehicle; IV control: treated intravenous Differential count of peripheral blood leukocytes were realized following 14 days exposure to LMM6 in single dose. Abbreviations; Healthy: normal mice; IP control: treated intraperitoneally with the vehicle; IV control: treated intravenous with the vehicle; IP LMM6: treated with 50 mg/kg of LMM6 intraperitoneally; IV LMM6: treated with 25 mg/kg of LMM6 intravenous. Values represent the mean ± SD. * p < 0.05, statistically significant changes compared with healthy control.