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. 2021 Mar 17;26(6):1677. doi: 10.3390/molecules26061677

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Effect of ODSO on the glucose-induced short-circuit current (Isc). (A) Typical recording of the inhibition of Isc (μA/cm²) across the mouse jejunum segment isolated in the Ussing chamber by phlorizin (PHZ) added on the mucosal side 10 min before the luminal d-glucose challenge (30 mM). This figure showed that PHZ induced the total inhibition of Isc. (B) ODSO (1 mg/mL) diluted in a Ringer solution was added on the mucosal side 10 min before the luminal d-glucose challenge (30 mM). An increase in Isc reflects glucose-related electrogenic sodium absorption through (Na+)-glucose cotransporter-1, SGLT1. The maximal increase in Isc was measured at the plateau. (C) The AUC of the vehicle and ODSO effects on d-glucose induced Isc. (D) The concentration-response inhibition of glucose-induced Isc is expressed as a % of the maximum effect induced by 0.5 mM of phlorizin (PHZ); n = 6–15 ** p < 0.001 tissues studied.

Effect of ODSO on the glucose-induced short-circuit current (Isc). (A) Typical recording of the inhibition of Isc (μA/cm²) across the mouse jejunum segment isolated in the Ussing chamber by phlorizin (PHZ) added on the mucosal side 10 min before the luminal d-glucose challenge (30 mM). This figure showed that PHZ induced the total inhibition of Isc. (B) ODSO (1 mg/mL) diluted in a Ringer solution was added on the mucosal side 10 min before the luminal d-glucose challenge (30 mM). An increase in Isc reflects glucose-related electrogenic sodium absorption through (Na+)-glucose cotransporter-1, SGLT1. The maximal increase in Isc was measured at the plateau. (C) The AUC of the vehicle and ODSO effects on d-glucose induced Isc. (D) The concentration-response inhibition of glucose-induced Isc is expressed as a % of the maximum effect induced by 0.5 mM of phlorizin (PHZ); n = 6–15 ** p < 0.001 tissues studied.