Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Mar 19;10(3):678. doi: 10.3390/cells10030678

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

The Transcriptional-Metabolic Interactions under Hypoxia. A variety of genes upregulated transcriptionally under hypoxia affect cancer cell metabolism and behavior. The balance of glycolysis and oxidative phosphorylation along with the amounts of cholesterol, triacylglycerols, and other metabolites can metabolically “prime” a cancer cell to seed at specific organs during metastasis. HK2: Hexokinase 2; GPI: Glucose-6-phosphate isomerase; PFKP: 6-phosphofructokinase platelet type; ALDOC: Aldolase C; GLUT1: Glucose transporter protein type 1; PGK1: Phosphoglycerate kinase 1; GAPDH: Glyceraldehyde-3-phosphate dehydrogenase; ENO1: Enolase 1; LDHA: Lactate dehydrogenase-A; G6PD: Glucose-6-phosphate dehydrogenase; PGLS: 6-phosphogluconolactonase; PGD: 6-phosphogluconate dehydrogenase; TKT: Transketolase; TALDO1: Transaldolase 1; ASCT2: Alanine-serine-cysteine transporter, type-2; OPN: Osteopontin, PLAU: Plasminogen activator urokinase receptor, LOX: Lysyl oxidase; UPR: Unfolded protein response; TCA: Tricarboxylic acid; ATP: Adenosine triphosphate.