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. 2021 Mar 19;13(3):411. doi: 10.3390/pharmaceutics13030411

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Graphs to show the in vitro oral gliding performance and shear adhesion profile of various film-coated tablets using a modified Hounsfield tensometer across an in vitro, non-anatomical model using artificial saliva wetted sodium polyacrylate (dashed lined) and polytetrafluoroethylene ramp surface (solid lines). HPMC and PVA possessed higher initiating detachment forces and displayed a greater gliding resistance in comparison to Opadry^® EZ (OEZ), which possessed the most optimal slippery profile in comparison to all film-coated formulations (ANOVA, p < 0.05). The addition of water-soluble polymers within KIR (Kollicoat^® IR) imparted lubricating properties, as substantially lower peak forces and gliding forces were recorded.