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. 2021 Mar 19;13(3):411. doi: 10.3390/pharmaceutics13030411

Table 2.

Apparent contact angle measurements with respect to time using sessile drop technique of film-coated tablets. Values equal to and below 90° correspond to increasingly hydrophilic surfaces in contrast to values above 90 corresponding to relatively more hydrophobic surfaces (un-wetting systems). Measurements were taken in triplicate and reported as mean value ± standard deviation. * The immediate apparent contact angle was recorded as the instant stable droplet contact on the tablet surface. HPMC: hydroxypropyl methylcellulose; PVA: polyvinyl alcohol.

Formulation Immediate * 10 s 20 s
Mean Std Mean Std Mean Std
Uncoated 0 0 0 0 0 0
Kollicoat® IR 97.17 1.46 89.92 1.59 83.32 1.33
Opadry® EZ 91.64 1.83 87.43 1.34 81.03 1.37
PVA 96.24 1.46 90.53 1.49 88.62 1.23
HPMC 94.28 1.21 89.24 1.36 86.13 1.16
C 1% w/w 93.06 1.92 88.73 1.21 75.77 1.31
C 3% w/w 88.67 1.24 81.97 1.25 73.03 1.83
Ge 1% w/w 98.37 1.37 93.07 1.15 80.87 1.31
Ge 3% w/w 104.17 1.55 91.17 1.04 82.87 1.82
Ge 3%: C1% w/w 93.23 1.53 86.07 1.54 76.33 1.22
Ge 3%: C3% w/w 89.57 1.64 81.87 1.42 71.08 1.36