Table 1.
Clinical and demographic characteristics of the study cohort.
| Demographics and Clinical Characteristics | Control | Early AMD |
Intermediate AMD | Late AMD |
|---|---|---|---|---|
| Number, n (%) | 18 (25.4) | 13 (18.3) | 31 (43.7) | 9 (12.7) |
| Number of eyes, n (%) | 31 (24.8) | 23 (18.4) | 56 (44.8) | 15 (12.0) |
| Included eye, n (%) | ||||
| OD | 16 (51.6) | 12 (52.2) | 26 (46.4) | 8 (53.3) |
| OS | 15 (48.4) | 11 (47.8) | 30 (53.6) | 7 (46.7) |
| Age, mean ± SD | 65.7 ± 7.8 | 66.1 ± 9.3 | 70.4 ± 5.4 | 71.4 ± 6.9 |
| Gender, n (%) | ||||
| Male | 10 (55.6) | 5 (38.5) | 12 (38.7) | 2 (22.2) |
| Female | 8 (44.4) | 8 (61.5) | 19 (61.3) | 7 (77.8) |
| BMI, mean ± SD | 26.2 ± 3.8 | 26.7 ± 4.5 | 28.0 ± 4.3 | 29.6 ± 5.3 |
| Race/ethnicity, n (%) | ||||
| White | 16 (88.9) | 10 (76.9) | 31 (100.0) | 7 (77.8) |
| Hispanic | 1 (5.6) | 2 (15.4) | 0 (0.0) | 2 (22.2) |
| Black | 1 (5.6) | 0 (0.0) | 0 (0.0) | 0 (0.0) |
| Asian | 0 (0.0) | 1 (7.7) | 0 (0.0) | 0 (0.0) |
| Smoking, n (%) | ||||
| Non-smoker | 8 (44.4) | 9 (69.2) | 13 (41.9) | 5 (55.6) |
| Ex-smoker | 9 (50.0) | 4 (30.8) | 17 (54.8) | 4 (44.4) |
| Smoker | 1 (5.6) | 0 (0.0) | 1 (3.2) | 0 (0.0) |
| AREDS formulation supplementation, n (%) | ||||
| No | 17 (94.4) | 12 (92.3) | 6 (19.4) | 2 (22.2) |
| Yes | 1 (5.6) | 1 (7.7) | 25 (80.6) | 7 (77.8) |
| Reticular Pseudodrusen, n (%) | ||||
| No | 16 (88.9) | 8 (61.5) | 7 (22.6) | 5 (55.6) |
| Yes | 2 (11.1) | 5 (38.5) | 24 (77.4) | 4 (44.4) |
| RIT, mean ± SD | 5.1 (2.8) | 6.7 (5.0) | 15.6 (5.3) | 12.1 (6.8) |
| AUDAC, mean ± SD | 0.06 (0.04) | 0.08 (0.07) | 0.19 (0.11) | 0.21 (0.19) |
AREDS = Age-Related Eye Disease Study; AUDAC = area under the dark adaptation curve BMI = body mass index; OD = right eye; OS = left eye; RIT = rod-intercept time.