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. 2021 Mar 21;9(3):319. doi: 10.3390/biomedicines9030319

Table 2.

Somatic and chromosomal mutations in relation to the WHO grade and subtype variants.

Grade I Grade II Grade III
Subtype (WHO grade) Meningothelial (TRAF7, AKT1, SMO,
PIK3CA, POLR2A)
Fibrous (NF2)
Transitional (NF2, PIK3CA, AKT1)
Psammomatous (NF2)
Angiomatous
Microcystic
Secretory (KLF4, TRAF7)
Lymphoplasmacyte-rich
Metaplastic
 Atypical (NF2, TRAF7, AKT1, TERT)
Clear cell (SMARCE1)
Choroid		 Anaplastic (NF2, TERT)
Rhadoid (BAP1)
Papillary
Gene Mutation graphic file with name biomedicines-09-00319-i001.jpg

Chromosomal Alterations
Loss: 22q


Inline graphic
Loss: 1p, 6q, 10, 14q, 18q
Gain: 1q, 9q, 12q, 15q, 17q,
20q
Inline graphic
Loss: 9p
Amplification: 17q