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. 2021 Mar 23;13(3):430. doi: 10.3390/pharmaceutics13030430

Figure 1.

Figure 1

Schematic representation of the conjugates, ZHER2–ABD–mcDM13 with drug-to-antibody ratio DAR = 3 (A), ZHER2–ABD–mcDM1 with DAR = 1 (B), and ZHER2–ABD–AA3 with DAR = 0 (C). The representations are not drawn to scale. ZHER2:2891, a 58 amino acids human epidermal growth factor receptor 2 (HER2) binding affibody molecule, is represented as a three-helix bundle in orange. The albumin binding domain (ABD), 46 amino acids, is represented as a three-helix bundle in blue. The drug mcDM1 is represented in purple (D) with the maleimidocaproyl linker in black.