Figure 5.

(A) In vitro binding specificity of radiolabeled AffiDCs to SKOV3 and BT474 cells, both with high HER2 expression. Non-blocked indicates cells that were incubated with the corresponding radiolabeled compound. Blocked indicates cells pre-incubated with non-radiolabeled conjugate to block available HER2 receptors prior to the incubation with the radiolabeled conjugate. Each bar is the average of three individual measurements, and the error bars in the panels correspond to 1 SD. The star signs (*) correspond to significant differences (p < 0.05). (B) the cellular processing of radiolabeled AffiDCs by SKOV3 and BT474 cells during continuous incubation over 24 h. Each data point is the average of three individual measurements, and the error bars in the panels correspond to 1 SD.